the cliff
Patent cliff
Drugs ranked by the soonest barrier to generic / biosimilar entry. Each row shows the earliest-expiring patent OR FDA exclusivity for that drug — whichever falls first determines when competitive pressure begins.
- Jun 7, 2027265dpatentFesoterodine Fumaratefesoterodine fumarateHetero USA Inc
- Jun 7, 2027265dD-192KlisyritirbanibulinAlmirall SA
- Jun 8, 2027266dpatentSafinamide Mesylatesafinamide mesylateZenara Pharma Pvt Ltd
- Jun 12, 2027270dNPPXigduo XR(dapagliflozin + metformin hydrochloride)AstraZeneca Pharmaceuticals LP
- Jun 13, 2027271dI-964Amvuttravutrisiran$ALNYALNYLAM PHARMACEUTICALS, INC.
- Jun 14, 2027272dpatentAnoro Ellipta(umeclidinium bromide + vilanterol trifenatate)GlaxoSmithKline LLC
- Jun 15, 2027273dpatentCarbinoxamine Maleatecarbinoxamine maleateMission Pharmacal Co
- Jun 15, 2027273dI-977Zepzelcalurbinectedin$JAZZJazz Pharmaceuticals plc
- Jun 19, 2027277dpatentMorphine Sulfate Actavismorphine sulfateTeva Pharmaceuticals USA Inc
- Jun 20, 2027278dpatentDAPAGLIFLOZINDAPAGLIFLOZINLupin Ltd
- Jun 21, 2027279dpatentOXYMORPHONE HYDROCHLORIDEOXYMORPHONE HYDROCHLORIDE$AVTRAvantor, Inc.
- Jun 21, 2027279dNPPWakixpitolisant hydrochloride$HRMYHarmony Biosciences Holdings, Inc.
- Jun 22, 2027280dODE*Xpovioselinexor$KPTIKaryopharm Therapeutics Inc.
- Jun 25, 2027283dODE-312Finteplafenfluramine hydrochlorideUCB SA
- Jun 26, 2027284dODE-474Mycapssaoctreotide acetateChiasma Inc
- Jun 26, 2027284dpatentVafseovadadustat$AKBAAkebia Therapeutics, Inc.
- Jun 30, 2027288dpatentApretudecabotegravirViiV Healthcare Company
- Jun 30, 2027288dpatentFomepizolefomepizoleNavinta LLC
- Jun 30, 2027288dODE-311Dojolvitriheptanoin$RAREUltragenyx Pharmaceutical Inc.
- Jul 5, 2027293dpatentDesvenlafaxine Succinatedesvenlafaxine succinateIntellipharmaceutics Ltd
- Jul 7, 2027295dODE-316Inqovi(cedazuridine + decitabine)Otsuka Pharmaceutical Co Ltd
- Jul 10, 2027298dpatentByfavoremimazolam besylateAcacia Pharma Group Ltd
- Jul 11, 2027299dpatentSpinrazanusinersen$BIIBBIOGEN INC.
- Jul 14, 2027302dpatentInvokamet XR(canagliflozin + metformin hydrochloride)Johnson & Johnson Innovative Medicine
- Jul 14, 2027302dpatentCANAGLIFLOZINCANAGLIFLOZINJohnson & Johnson Innovative Medicine
- Jul 20, 2027308dpatentCalcium Acetatecalcium acetateNostrum Pharmaceuticals LLC
- Jul 21, 2027309dODE-361Xywavsodium oxybate$JAZZJazz Pharmaceuticals plc
- Jul 22, 2027310dNPMerzee(ethinylestradiol + norethindrone acetate)Wilshire Pharmaceuticals Inc
- Jul 23, 2027311dpatentBUPRENORPHINE HYDROCHLORIDEBUPRENORPHINE HYDROCHLORIDEBioDelivery Sciences International Inc
- Jul 23, 2027311dpatentFentorafentanyl citrateTeva Pharmaceuticals USA Inc
- Jul 23, 2027311dpatentTpoxxtecovirimat$NNVCNANOVIRICIDES, INC.
- Jul 23, 2027311dpatentVardenafil Hydrochloridevardenafil hydrochlorideMacleods Pharma USA Inc
- Jul 24, 2027312dpatentLialdamesalamineTakeda Pharmaceuticals USA Inc
- Jul 28, 2027316dpatentDopteletavatrombopag maleateSwedish Orphan Biovitrum AB
- Aug 1, 2027320dpatentSalonpasmethyl salicylate [INN]Hisamitsu America Inc
- Aug 1, 2027320dpatentELTROMBOPAG OLAMINEELTROMBOPAG OLAMINE$AMRXAmneal Pharmaceuticals, Inc.
- Aug 3, 2027322dpatentRelistormethylnaltrexone bromideSalix Pharmaceuticals Ltd
- Aug 3, 2027322dpatentPrednisoneprednisone [INN]Vintage Pharmaceuticals Inc (Inactive)
- Aug 5, 2027324dODE-315MAGNESIUM SULFATEMAGNESIUM SULFATEMilla Pharmaceuticals Inc
- Aug 6, 2027325dpatentNinlaroixazomib citrateMillennium Pharmaceuticals Inc
- Aug 6, 2027325dODE-319Lampitnifurtimox [INN]Bayer HealthCare Pharmaceuticals Inc
- Aug 7, 2027326dNPDhivy(carbidopa + levodopa)Avion Pharmaceuticals LLC
- Aug 7, 2027326dI-949Fabhaltaiptacopan hydrochloride$NVSNOVARTIS AG
- Aug 12, 2027331dpatentAkeega(abiraterone acetate + niraparib)$JNJJOHNSON & JOHNSON
- Aug 12, 2027331dpatentIluvienfluocinolone acetonideAlimera Sciences Inc
- Aug 12, 2027331dpatentRubracarucaparib camsylatepharmaand GmbH
- Aug 12, 2027331dODE-280ViltepsoviltolarsenNS Pharma Inc
- Aug 13, 2027332dpatentDesonide ActavisdesonideTeva Pharmaceuticals USA Inc
- Aug 17, 2027336dpatentXuridenuridine triacetateBTG International Inc
- Aug 19, 2027338dpatentJuxtapidlomitapideChiesi USA Inc
sourced from FDA Orange Book · approved drugs only · biologics + biosimilars excluded (those live in the Purple Book — coming soon)