the cliff
Patent cliff
Drugs ranked by the soonest barrier to generic / biosimilar entry. Each row shows the earliest-expiring patent OR FDA exclusivity for that drug — whichever falls first determines when competitive pressure begins.
- Jan 19, 202780dNPPApremilastapremilastAnnora Pharma Pvt Ltd
- Jan 19, 202780dI-930Balversaerdafitinib$JNJJOHNSON & JOHNSON
- Jan 19, 202780dpatentStriverdi Respimatolodaterol hydrochlorideBoehringer Ingelheim Corp
- Jan 20, 202781dpatentKyproliscarfilzomib$AMGNAMGEN INC
- Jan 20, 202781dpatentBendaviaelamipretide hydrochlorideStealth BioTherapeutics Inc
- Jan 22, 202783dpatentActoplus Met(metformin hydrochloride + pioglitazone hydrochloride)Takeda Pharmaceuticals USA Inc
- Jan 23, 202784dpatentVyxeos(cytarabine hydrochloride + daunorubicin hydrochloride)$JAZZJazz Pharmaceuticals plc
- Jan 23, 202784dpatentAmitizalubiprostoneMallinckrodt LLC
- Jan 24, 202785dODE-367DificidfidaxomicinCubist Pharmaceuticals LLC
- Jan 25, 202786dpatentFentanylfentanylActavis Elizabeth LLC
- Jan 26, 202787dpatentProcysbicysteamineHorizon Therapeutics USA Inc
- Jan 30, 202791dpatentDuetact(glimepiride + pioglitazone hydrochloride)Takeda Pharmaceuticals USA Inc
- Jan 31, 202792dpatentIlevronepafenac$HROWHARROW, INC.
- Feb 1, 202793dpatentMalathionSuven Life Sciences Ltd
- Feb 2, 202794dpatentEPOPROSTENOL SODIUMEPOPROSTENOL SODIUMJanssen-Cilag Holdings Inc (Inactive)
- Feb 2, 202794dpatentREGADENOSONREGADENOSONAPOTEX
- Feb 2, 202794dpatentRayaldeecalcifediolOPKO Pharmaceuticals LLC
- Feb 2, 202794dpatentDexlansoprazoledexlansoprazoleTWi Pharmaceuticals USA Inc
- Feb 7, 202799dpatentPlan B One-SteplevonorgestrelFoundation Consumer Healthcare LLC
- Feb 9, 2027101dpatentavutometinib potassium$VSTMVerastem, Inc.
- Feb 12, 2027104dpatentRapivabperamivir$BCRXBIOCRYST PHARMACEUTICALS INC
- Feb 13, 2027105dNPAurlumyniloprostBTG International Inc
- Feb 13, 2027105dpatentAbraxanepaclitaxelCelgene Corp
- Feb 16, 2027108dpatentEucrisacrisaborole$PFEPFIZER INC
- Feb 16, 2027108dI-941Tagrissoosimertinib mesylate$AZNASTRAZENECA PLC
- Feb 17, 2027109dNCEPyrukyndmitapivat sulfate$AGIOAGIOS PHARMACEUTICALS, INC.
- Feb 23, 2027115dI-942Biktarvy(bictegravir sodium + emtricitabine + tenofovir alafenamide)$GILDGILEAD SCIENCES, INC.
- Feb 24, 2027116dpatentBalsalazide Disodiumbalsalazide disodiumCarnegie Pharmaceuticals LLC
- Feb 26, 2027118dpatentTestosterone PartestosteronePar Pharmaceutical Inc
- Feb 27, 2027119dpatentGenvoya(cobicistat + elvitegravir + emtricitabine + tenofovir alafenamide fumarate)$GILDGILEAD SCIENCES, INC.
- Feb 27, 2027119dpatentStribild(cobicistat + elvitegravir + emtricitabine + tenofovir disoproxil fumarate)$GILDGILEAD SCIENCES, INC.
- Feb 28, 2027120dpatentAdvil Allergy Sinus(chlorpheniramine maleate + ibuprofen + pseudoephedrine hydrochloride)$HLNHaleon plc
- Feb 28, 2027120dpatentLinzesslinaclotide$ABBVAbbVie Inc.
- Feb 28, 2027120dNCEVonjopacritinibSobi Inc
- Mar 2, 2027122dpatentAbilify MaintenaaripiprazoleOtsuka America Pharmaceutical Inc
- Mar 4, 2027124dNPClobetasol Propionateclobetasol propionateTeva Pharmaceuticals USA Inc
- Mar 5, 2027125dpatentIbrancepalbociclib$OTLCOncotelic Therapeutics, Inc.
- Mar 6, 2027126dPEDOfevnintedanib esylateBoehringer Ingelheim Corp
- Mar 6, 2027126dODE-286Isturisaosilodrostat phosphateRecordati Rare Diseases Inc
- Mar 7, 2027127dpatentMINOCYCLINE HYDROCHLORIDEMINOCYCLINE HYDROCHLORIDEThe Medicines Co
- Mar 8, 2027128dI-935WegovysemaglutideNovo Nordisk Inc
- Mar 10, 2027130dpatentDuavee(bazedoxifene acetate + conjugated estrogens)$PFEPFIZER INC
- Mar 11, 2027131dpatentOpsynvi(macitentan + tadalafil)Janssen Biotech Inc
- Mar 11, 2027131dpatentMACITENTANMACITENTAN$JNJJOHNSON & JOHNSON
- Mar 11, 2027131dpatentZolinzavorinostat$MRKMerck & Co., Inc.
- Mar 12, 2027132dpatentTeriflunomideteriflunomideSOLA Pharmaceuticals Inc
- Mar 13, 2027133dpatentMektovibinimetinibArray BioPharma Inc
- Mar 13, 2027133dI-938Livmarlimaralixibat chloride$MIRMMirum Pharmaceuticals, Inc.
- Mar 14, 2027134dpatentVeltassapatiromer sorbitex calciumVifor Pharma Inc
- Mar 15, 2027135dpatentDYANAVEL XR 20AMPHETAMINE$TRAWTraws Pharma, Inc.
sourced from FDA Orange Book · approved drugs only · biologics + biosimilars excluded (those live in the Purple Book — coming soon)