pharmadog
News
when
  • Latest
  • Archive
by source
  • All Sources
  • Sources Page
Jobs
department
  • Clinical
  • Regulatory
  • Medical Affairs
  • Commercial
  • R&D / Discovery
  • Biostatistics / Data
  • Manufacturing / CMC
  • Market Access
therapeutic area
  • Oncology
  • Immunology
  • Neuroscience
  • Cardiovascular
  • Metabolic
  • Rare Disease
  • Infectious Disease
location & type
  • Remote Only
  • US Only
  • California
  • Massachusetts
  • Internships
  • Phase 3 Roles
  • All Jobs →
Sign InSubscribe
pharmadog

fetch the data · sniff the signal

Discover
  • Jobs
  • News
Hubs
  • Topics
  • Patent cliff
  • Publications
Tools
  • Compare
  • Search
  • Bookmarks
Trust
  • About
  • Sources
  • Contact
Legal
  • Privacy
  • Terms
  • Pricing

© 2026 pharmadog.xyz

made by humans and a good dog

  • home
  • jobs
  • news
  • search
  1. pharmadog
  2. ›drugs
  3. ›Linzess
drug
save

linaclotide

Marketedupdated 3mo ago
by $ABBV AbbVie Inc.
Approved
community read0 votes

🐶 often sniffed alongside

top 3
  • tagApproval76 co-mentions · 19 sources
  • drugLINZESS76 co-mentions · 19 sources
  • tagSmall Molecule38 co-mentions · 19 sources

Protein drug with a maximum clinical stage of Approval (across all indications), with 3 approved and 3 investigational indications.

all catalysts(19)

approval · 19
Aug 30, 2012
approval
$ABBV265.97+2.72%
14y ago
LINZESS (LINACLOTIDE) — FDA approval
linaclotide
→
Aug 8, 2013
approval
$ABBV265.97+2.72%
13y ago
LINZESS (LINACLOTIDE) — FDA approval
linaclotide
→
Nov 8, 2013
approval
$ABBV265.97+2.72%
13y ago
LINZESS (LINACLOTIDE) — FDA approval
linaclotide
→
Jul 1, 2014
approval
$ABBV265.97+2.72%
12y ago
LINZESS (LINACLOTIDE) — FDA approval
linaclotide
→
Jul 9, 2014
approval
$ABBV265.97+2.72%
12y ago
LINZESS (LINACLOTIDE) — FDA approval
linaclotide
→
Dec 11, 2014
approval
$ABBV265.97+2.72%
12y ago
LINZESS (LINACLOTIDE) — FDA approval
linaclotide
→
Jan 5, 2015
approval
$ABBV265.97+2.72%
12y ago
LINZESS (LINACLOTIDE) — FDA approval
linaclotide
→
Nov 23, 2015
approval
$ABBV265.97+2.72%
11y ago
LINZESS (LINACLOTIDE) — FDA approval
linaclotide
→
Apr 6, 2016
approval
$ABBV265.97+2.72%
10y ago
LINZESS (LINACLOTIDE) — FDA approval
linaclotide
→
May 18, 2016
approval
$ABBV265.97+2.72%
10y ago
LINZESS (LINACLOTIDE) — FDA approval
linaclotide
→
Aug 31, 2016
approval
$ABBV265.97+2.72%
10y ago
LINZESS (LINACLOTIDE) — FDA approval
linaclotide
→
Jan 6, 2017
approval
$ABBV265.97+2.72%
10y ago
LINZESS (LINACLOTIDE) — FDA approval
linaclotide
→
Jan 25, 2017
approval
$ABBV265.97+2.72%
10y ago
LINZESS (LINACLOTIDE) — FDA approval
linaclotide
→
Mar 8, 2017
approval
$ABBV265.97+2.72%
9y ago
LINZESS (LINACLOTIDE) — FDA approval
linaclotide
→
Sep 22, 2020
approval
$ABBV265.97+2.72%
6y ago
LINZESS (LINACLOTIDE) — FDA approval
linaclotide
→
Apr 12, 2021
approval
$ABBV265.97+2.72%
5y ago
LINZESS (LINACLOTIDE) — FDA approval
linaclotide
→
Aug 24, 2021
approval
$ABBV265.97+2.72%
5y ago
LINZESS (LINACLOTIDE) — FDA approval
linaclotide
→
Jun 12, 2023
approval
$ABBV265.97+2.72%
3y ago
LINZESS (LINACLOTIDE) — FDA approval
linaclotide
→
Nov 4, 2025
approval
$ABBV265.97+2.72%
10mo ago
LINZESS (LINACLOTIDE) — FDA approval
linaclotide
→
view all 19 catalysts →

Trials studying linaclotide

  • phase2A Study to Assess Adverse Events and Change in Disease Activity in Pediatric Participants (Age 6 Months to <2 Years) With Functional Constipation Who Are Treated With Linaclotidecompletedn=19
  • phase3A Study to Assess Adverse Events and Change in Symptoms With Linaclotide Versus Placebo in Pediatric Subjects, Ages 2 to 5 Years, With Functional Constipationcompletedn=123
  • phase3Linaclotide Safety and Efficacy in Pediatric Participants, 6 to 17 Years of Age, With Irritable Bowel Syndrome With Constipation (IBS-C) or Functional Constipation (FC)completedn=438
  • —Post-marketing Surveillance of Linaclotide Tablet in Patients With Irritable Bowel Syndrome With Constipation or Chronic Constipation (Excluding Constipation Due to Organic Diseases)completedn=2,475
  • phase3A Study of Oral Dosing of ASP0456 in Patients With Chronic Constipationcompletedn=186
  • phase2A Study to Evaluate the Effect of ASP0456 in Patients With Constipation Predominant Irritable Bowel Syndromecompletedn=559
  • phase3Phase III Study to Evaluate the Efficacy and Safety of ASP0456 in Patients With Constipation Predominant Irritable Bowel Syndromecompletedn=500

Patent cliff

source: FDA Orange Book
first barrier falls
Aug 30, 2026
10 days

Earliest of all listed patents + FDA exclusivities. Generic / biosimilar entry typically only becomes possible AFTER both patent and exclusivity barriers expire.

patents (30)

  • Feb 16, 2034patentUS 9708371*PED
  • Feb 16, 2034patentUS 9708371*PED
  • Feb 16, 2034patentUS 9708371*PED
  • Aug 16, 2033formulationUS 9708371
  • Aug 16, 2033formulationUS 9708371
  • Aug 16, 2033formulationUS 9708371
  • Apr 30, 2032patentUS 8748573*PED
  • Apr 30, 2032patentUS 8748573*PED
  • Apr 30, 2032patentUS 8802628*PED
  • Apr 30, 2032patentUS 8802628*PED
  • Feb 11, 2032patentUS 10675325*PED
  • Feb 11, 2032patentUS 10702576*PED
  • Oct 30, 2031method-of-use (U-1515)US 8748573
  • Oct 30, 2031method-of-use (U-4345)US 8748573
  • Oct 30, 2031formulationUS 8802628
  • Oct 30, 2031formulationUS 8802628
  • Aug 17, 2031patentUS 8933030*PED5.0y
  • Aug 17, 2031patentUS 8933030*PED5.0y
  • Aug 17, 2031patentUS 8933030*PED5.0y
  • Aug 11, 2031formulationUS 106753255.0y
  • Aug 11, 2031method-of-use (U-3644)US 107025765.0y
  • Feb 17, 2031formulationUS 89330304.5y
  • Feb 17, 2031formulationUS 89330304.5y
  • Feb 17, 2031formulationUS 89330304.5y
  • Feb 28, 2027patentUS 7304036*PED192d
  • Feb 28, 2027patentUS 7304036*PED192d
  • Feb 28, 2027patentUS 7304036*PED192d
  • Aug 30, 2026compositionUS 730403610d
  • Aug 30, 2026compositionUS 730403610d
  • Aug 30, 2026compositionUS 730403610d

FDA exclusivities (4)

  • May 4, 2029PEDPediatric (6mo bonus)2.7y
  • Nov 4, 2028NPPNew Product (3y)2.2y
  • Jun 12, 2026I-921Indication (3y)
  • Jun 12, 2026I-921Indication (3y)

News(0)

no news has mentioned this drug yet

brand
Linzess
generic
linaclotide
MOA
12.1 Mechanism of Action Linaclotide is structurally related to human guanylin and uroguanylin and functions as a guanylate cyclase-C (GC-C) agonist. Both linaclotide and its active metabolite bind to GC-C and act locally on the luminal surface of the intestinal epithelium. Activation of GC-C results in an increase in both intracellular and extracellular concentrations of cyclic guanosine monophosphate (cGMP). Elevation in intracellular cGMP stimulates secretion of chloride and bicarbonate into the intestinal lumen, mainly through activation of the cystic fibrosis transmembrane conductance regulator (CFTR) ion channel, resulting in increased intestinal fluid and accelerated transit. In animal models, linaclotide has been shown to both accelerate GI transit and reduce intestinal pain. In an animal model of visceral pain, linaclotide reduced abdominal muscle contraction and decreased the activity of pain-sensing nerves by increasing extracellular cGMP.
indication
Constipation
phase
marketed
Data sources
openFDA · ClinicalTrials.gov
last refreshed 2m ago
Found something off?
🐶 something off?

Report a data issue

Tell Bork what looks wrong — wrong sponsor, stale phase, mislinked ticker, anything. We’ll triage and fix.

comments(0)

5-min edit window · permanent after that
sign in to leave a comment · permanent archive after 5 minutes
no comments yet — first sniff?