the cliff
Patent cliff
Drugs ranked by the soonest barrier to generic / biosimilar entry. Each row shows the earliest-expiring patent OR FDA exclusivity for that drug — whichever falls first determines when competitive pressure begins.
- Dec 7, 202683dpatentPANTOPRAZOLE SODIUMPANTOPRAZOLE SODIUMKnack Pharmaceuticals Inc
- Dec 8, 202684dpatentLarotidamoxicillinNeoPharma Inc
- Dec 8, 202684dGAINCresembaisavuconazonium sulfateAstellas Pharma US Inc
- Dec 12, 202688dpatentEpinephrineepinephrineInternational Medication Systems Ltd
- Dec 12, 202688dODE-280Vyondys 53golodirsen$SRPTSarepta Therapeutics, Inc.
- Dec 12, 202688dpatentNarcannaloxone hydrochlorideEmergent Devices Inc
- Dec 12, 202688dpatentKoselugoselumetinib sulfateAstraZeneca Pharmaceuticals LP
- Dec 13, 202689dNPTRAVOPROSTTRAVOPROSTSandoz Inc
- Dec 13, 202689dNPIwilfineflornithine hydrochlorideUS WorldMeds LLC
- Dec 14, 202690dI-931Weliregbelzutifan$MRKMerck & Co., Inc.
- Dec 14, 202690dpatentSigniforpasireotideRecordati Corp
- Dec 15, 202691dPEDTriumeq(abacavir sulfate + dolutegravir sodium + lamivudine)ViiV Healthcare Company
- Dec 16, 202692dpatentInrebicfedratinibBristol-Myers Squibb Co
- Dec 17, 202693dpatentTrintellixvortioxetine hydrobromideTakeda Pharmaceuticals USA Inc
- Dec 19, 202695dpatentLatissebimatoprost$ABBVAbbVie Inc.
- Dec 19, 202695dpatentVyndamaxtafamidis$PFEPFIZER INC
- Dec 20, 202696dPEDSynjardy XR(empagliflozin + metformin hydrochloride)Boehringer Ingelheim Corp
- Dec 20, 202696dPEDLinagliptin + Metformin Hydrochloride(linagliptin + metformin hydrochloride)MSN Pharmaceuticals Inc
- Dec 20, 202696dPEDLINAGLIPTINLINAGLIPTINBoehringer Ingelheim Corp
- Dec 20, 202696dpatentVykat XRdiazoxide choline$SLNOSOLENO THERAPEUTICS INC
- Dec 22, 202698dI-985Leqvioinclisiran$NVSNOVARTIS AG
- Dec 22, 202698dpatentIclusigponatinib hydrochloride$TAKTAKEDA PHARMACEUTICAL CO LTD
- Dec 26, 2026102dpatentSymtuza(cobicistat + darunavir + emtricitabine + tenofovir alafenamide)$JNJJOHNSON & JOHNSON
- Dec 26, 2026102dpatentPrezcobix(cobicistat + darunavir)$JNJJOHNSON & JOHNSON
- Dec 26, 2026102dpatentPrezistadarunavirJanssen Therapeutics
- Dec 27, 2026103dpatentRyteloimetelstat sodium$GERNGERON CORP
- Dec 27, 2026103dODE-283LynparzaolaparibAstraZeneca Pharmaceuticals LP
- Dec 28, 2026104dpatentAlyftrek(deutivacaftor + tezacaftor + vanzacaftor calcium)$VERXVertex, Inc.
- Dec 28, 2026104dpatentImbruvicaibrutinib$ABBVAbbVie Inc.
- Dec 30, 2026106dNCE*Recorlevlevoketoconazole$XERSXeris Biopharma Holdings, Inc.
- Jan 1, 2027108dpatentVibativtelavancin hydrochloride$CPIXCUMBERLAND PHARMACEUTICALS INC
- Jan 3, 2027110dPEDNucynta ERtapentadol hydrochloride$COLLCOLLEGIUM PHARMACEUTICAL, INC
- Jan 5, 2027112dpatentZalvisosufentanil citrate$TLPHTALPHERA, INC.
- Jan 6, 2027113dpatentCamptosaririnotecan hydrochloride$PFEPFIZER INC
- Jan 6, 2027113dpatentJatenzotestosterone undecanoate$LPCNLipocine Inc.
- Jan 8, 2027115dM-303METHYLENE BLUEMETHYLENE BLUENexus Pharmaceuticals Inc
- Jan 8, 2027115dpatentHalaveneribulin mesylateEisai Co Ltd
- Jan 8, 2027115dpatentInjectaferferric carboxymaltoseAmerican Regent Inc
- Jan 9, 2027116dODE-356AyvakitavapritinibBlueprint Medicines Corp
- Jan 10, 2027117dNPPDIAZEPAMDIAZEPAMMylan Institutional Inc
- Jan 10, 2027117dpatentSublocadebuprenorphine [INN]$INDVIndivior Pharmaceuticals, Inc.
- Jan 12, 2027119dpatentWinleviclascoteroneSun Pharmaceutical Industries Ltd
- Jan 13, 2027120dPEDVekluryremdesivir$GILDGILEAD SCIENCES, INC.
- Jan 14, 2027121dNCECibinqoabrocitinib$PFEPFIZER INC
- Jan 15, 2027122dpatentDuvyzatgivinostat hydrochlorideItalfarmaco SpA
- Jan 16, 2027123dpatentCamcevileuprolide mesylateForesee Pharmaceuticals Co Ltd
- Jan 18, 2027125dpatentNILOTINIB HYDROCHLORIDENILOTINIB HYDROCHLORIDEHetero Labs Ltd
- Jan 18, 2027125dI-937Piqrayalpelisib$NVSNOVARTIS AG
- Jan 19, 2027126dpatentStiolto Respimat(olodaterol hydrochloride + tiotropium bromide)Boehringer Ingelheim Corp
- Jan 19, 2027126dNPPApremilastapremilastAnnora Pharma Pvt Ltd
sourced from FDA Orange Book · approved drugs only · biologics + biosimilars excluded (those live in the Purple Book — coming soon)