the cliff
Patent cliff
Drugs ranked by the soonest barrier to generic / biosimilar entry. Each row shows the earliest-expiring patent OR FDA exclusivity for that drug — whichever falls first determines when competitive pressure begins.
- Oct 3, 202688dODE-271Hemadydexamethasone [INN]Fera Pharmaceuticals LLC
- Oct 4, 202689dpatentAriceptdonepezil hydrochlorideEisai Co Ltd
- Oct 4, 202689dpatentMethotrexate Sodiummethotrexate$PFEPFIZER INC
- Oct 4, 202689dpatentXyostedtestosterone enanthateAntares Pharma Inc
- Oct 5, 202690dI-969Zoryveroflumilast$ARQTArcutis Biotherapeutics, Inc.
- Oct 5, 202690dpatentCotelliccobimetinib fumarateGenentech Inc
- Oct 5, 202690dpatentSymproicnaldemedine tosylateBioDelivery Sciences International Inc
- Oct 6, 202691dpatentASENAPINE MALEATEASENAPINE MALEATENoven Pharmaceuticals Inc
- Oct 7, 202692dNCETavneosavacopanChemoCentryx Inc
- Oct 8, 202693dODE-270Scenesseafamelanotide acetateClinuvel Pharmaceuticals Ltd
- Oct 11, 202696dI-928MektovibinimetinibArray BioPharma Inc
- Oct 11, 202696dI-928BraftoviencorafenibArray BioPharma Inc
- Oct 11, 202696dpatentSimvastatinsimvastatinYiling Pharmaceutical Ltd
- Oct 12, 202697dpatentBREXPIPRAZOLEBREXPIPRAZOLE$AMRXAmneal Pharmaceuticals, Inc.
- Oct 12, 202697dpatentTestosterone PartestosteronePar Pharmaceutical Inc
- Oct 17, 2026102dNPPILOCARPINE HYDROCHLORIDEPILOCARPINE HYDROCHLORIDEInnogenix Inc
- Oct 17, 2026102dNPXphozahtenapanor hydrochloride$ARDXARDELYX, INC.
- Oct 17, 2026102dNPAcetaminophenacetaminophenGranules USA Inc
- Oct 17, 2026102dpatentNoxiventnitric oxide$LINLINDE PLC
- Oct 18, 2026103dM-14Savaysaedoxaban tosylateDaiichi Sankyo Co Ltd
- Oct 20, 2026105dNPCabtreo(adapalene + benzoyl peroxide + clindamycin phosphate)Bausch Health US LLC
- Oct 20, 2026105dM-270Epidiolexcannabidiol$JAZZJazz Pharmaceuticals plc
- Oct 20, 2026105dNCEVoxzogovosoritide$BMRNBIOMARIN PHARMACEUTICAL INC
- Oct 21, 2026106dM-313TRIKAFTA (COPACKAGED)ELEXACAFTOR, IVACAFTOR, TEZACAFTOR$VERXVertex, Inc.
- Oct 23, 2026108dpatentAdasuveloxapineAlexza Pharmaceuticals Inc
- Oct 23, 2026108dODE-277Zejulaniraparib$JNJJOHNSON & JOHNSON
- Oct 24, 2026109dI-924TibsovoivosidenibLes Laboratoires Servier SAS
- Oct 25, 2026110dpatentSyfovrepegcetacoplan$APLSApellis Pharmaceuticals, Inc.
- Oct 26, 2026111dpatentomacetaxine mepesuccinate$TEVATEVA PHARMACEUTICAL INDUSTRIES LTD
- Oct 29, 2026114dI-953Scemblixasciminib hydrochloride$NVSNOVARTIS AG
- Oct 29, 2026114dM-14Kalydecoivacaftor$VERXVertex, Inc.
- Oct 30, 2026115dI-967Mavyret(glecaprevir + pibrentasvir)$ABBVAbbVie Inc.
- Oct 31, 2026116dpatentSELEXIPAGSELEXIPAG$JNJJOHNSON & JOHNSON
- Nov 1, 2026117dGAINVoqueznavonoprazan fumarate$PHATPhathom Pharmaceuticals, Inc.
- Nov 2, 2026118dpatentPREGABALINPREGABALINRK Pharma Inc
- Nov 8, 2026124dpatentOrkambi(ivacaftor + lumacaftor)$VERXVertex, Inc.
- Nov 8, 2026124dpatentSacubitril + Valsartan(sacubitril + valsartan)Novugen Pharma (Malaysia) Sdn Bhd
- Nov 8, 2026124dpatentSACUBITRIL AND VALSARTANSACUBITRILSomerset Therapeutics LLC
- Nov 8, 2026124dI-958ZEPBOUNDTIRZEPATIDE$LLYELI LILLY & Co
- Nov 9, 2026125dpatentTarpeyobudesonideCalliditas Therapeutics AB
- Nov 9, 2026125dI-929ExparelbupivacaineAllay Therapeutics Inc
- Nov 10, 2026126dpatentHorizantgabapentin enacarbilAzurity Pharmaceuticals Inc
- Nov 11, 2026127dpatentIzervayavacincaptad pegol sodiumAstellas Pharma US Inc
- Nov 12, 2026128dpatentEmblaveo(avibactam sodium + aztreonam)$ABBVAbbVie Inc.
- Nov 12, 2026128dpatentAvycaz(avibactam sodium + ceftazidime)$ABBVAbbVie Inc.
- Nov 13, 2026129dPEDBreo Ellipta(fluticasone furoate + vilanterol trifenatate)GlaxoSmithKline LLC
- Nov 13, 2026129dpatentSofdrasofpironium bromideBotanix Pharmaceuticals Ltd
- Nov 14, 2026130dI-936Brukinsazanubrutinib$ONCBeOne Medicines Ltd.
- Nov 15, 2026131dpatentHernexeoszongertinibBoehringer Ingelheim Corp
- Nov 20, 2026136dODE-273Givlaarigivosiran$ALNYALNYLAM PHARMACEUTICALS, INC.
sourced from FDA Orange Book · approved drugs only · biologics + biosimilars excluded (those live in the Purple Book — coming soon)