the cliff
Patent cliff
Drugs ranked by the soonest barrier to generic / biosimilar entry. Each row shows the earliest-expiring patent OR FDA exclusivity for that drug — whichever falls first determines when competitive pressure begins.
- Sep 15, 20260dpatentAdapaleneadapalenePL Developments Copiague LLC
- Sep 15, 20260dpatentLynkuetelinzanetantBayer USA LLC
- Sep 16, 20261dCGTCITALOPRAM HYDROBROMIDECITALOPRAM HYDROBROMIDEInvaGen Pharmaceuticals Inc
- Sep 16, 20261dODE-428Mekinisttrametinib dimethyl sulfoxide$NVSNOVARTIS AG
- Sep 16, 20261dODE-428Tafinlardabrafenib mesylate$NVSNOVARTIS AG
- Sep 19, 20264dpatentLenvimalenvatinib mesylateEisai Co Ltd
- Sep 20, 20265dCGTFluticasone Propionatefluticasone propionateGlenmark Pharmaceuticals Ltd
- Sep 21, 20266dI-922SYNJARDYEMPAGLIFLOZINBoehringer Ingelheim Corp
- Sep 22, 20267dpatentCINACALCET HYDROCHLORIDECINACALCET HYDROCHLORIDESlate Run Pharmaceuticals LLC
- Sep 22, 20267dpatentPIRFENIDONEPIRFENIDONEAizant Drug Research Solutions Pvt Ltd
- Sep 25, 202610dNPRyzumviphentolamine mesylate$IRDOpus Genetics, Inc.
- Sep 26, 202611dI-923BosutinibbosutinibAlembic Pharmaceuticals Inc
- Sep 26, 202611dpatentRisperidonerisperidoneSenores Pharmaceuticals Inc
- Sep 27, 202612dpatentDexlansoprazoledexlansoprazoleTWi Pharmaceuticals USA Inc
- Sep 28, 202613dpatentDASATINIBDASATINIBXspray Pharma AB
- Sep 28, 202613dNCEQuliptaatogepant$ABBVAbbVie Inc.
- Sep 28, 202613dNPOpfoldamiglustatBiocodex
- Sep 29, 202614dI-938Livmarlimaralixibat chloride$MIRMMirum Pharmaceuticals, Inc.
- Oct 2, 202617dpatentBaxdeladelafloxacin meglumineMelinta Therapeutics LLC
- Oct 2, 202617dNPPVeltassapatiromer sorbitex calciumVifor Pharma Inc
- Oct 2, 202617dpatentVeregensinecatechins$ANIPANI PHARMACEUTICALS INC
- Oct 3, 202618dM-270EVRYSDIRISDIPLAMGenentech Inc
- Oct 3, 202618dODE-271Hemadydexamethasone [INN]Fera Pharmaceuticals LLC
- Oct 4, 202619dpatentAriceptdonepezil hydrochlorideEisai Co Ltd
- Oct 4, 202619dpatentMethotrexate Sodiummethotrexate$PFEPFIZER INC
- Oct 4, 202619dpatentXyostedtestosterone enanthateAntares Pharma Inc
- Oct 5, 202620dI-969Zoryveroflumilast$ARQTArcutis Biotherapeutics, Inc.
- Oct 5, 202620dpatentCotelliccobimetinib fumarateGenentech Inc
- Oct 5, 202620dpatentSymproicnaldemedine tosylateBioDelivery Sciences International Inc
- Oct 6, 202621dpatentASENAPINE MALEATEASENAPINE MALEATENoven Pharmaceuticals Inc
- Oct 7, 202622dNCETavneosavacopanChemoCentryx Inc
- Oct 8, 202623dODE-270Scenesseafamelanotide acetateClinuvel Pharmaceuticals Ltd
- Oct 11, 202626dI-928MektovibinimetinibArray BioPharma Inc
- Oct 11, 202626dI-928BraftoviencorafenibArray BioPharma Inc
- Oct 11, 202626dpatentSimvastatinsimvastatinYiling Pharmaceutical Ltd
- Oct 12, 202627dpatentBREXPIPRAZOLEBREXPIPRAZOLE$AMRXAmneal Pharmaceuticals, Inc.
- Oct 12, 202627dpatentTestosterone PartestosteronePar Pharmaceutical Inc
- Oct 17, 202632dNPPILOCARPINE HYDROCHLORIDEPILOCARPINE HYDROCHLORIDEInnogenix Inc
- Oct 17, 202632dNPXphozahtenapanor hydrochloride$ARDXARDELYX, INC.
- Oct 17, 202632dNPAcetaminophenacetaminophenGranules USA Inc
- Oct 17, 202632dpatentNoxiventnitric oxide$LINLINDE PLC
- Oct 18, 202633dM-14Savaysaedoxaban tosylateDaiichi Sankyo Co Ltd
- Oct 18, 202633dODE-272Orenitramtreprostinil diolamine$UTHRUNITED THERAPEUTICS Corp
- Oct 20, 202635dNPCabtreo(adapalene + benzoyl peroxide + clindamycin phosphate)Bausch Health US LLC
- Oct 20, 202635dM-270Epidiolexcannabidiol$JAZZJazz Pharmaceuticals plc
- Oct 20, 202635dNPRozlytrekentrectinibF. Hoffmann-La Roche Ltd
- Oct 20, 202635dNCEVoxzogovosoritide$BMRNBIOMARIN PHARMACEUTICAL INC
- Oct 21, 202636dM-313TRIKAFTA (COPACKAGED)ELEXACAFTOR, IVACAFTOR, TEZACAFTOR$VERXVertex, Inc.
- Oct 22, 202637dPEDIvabradine Hydrochlorideivabradine hydrochlorideIngenus Pharmaceuticals LLC
- Oct 22, 202637dpatentZelborafvemurafenibF. Hoffmann-La Roche Ltd
sourced from FDA Orange Book · approved drugs only · biologics + biosimilars excluded (those live in the Purple Book — coming soon)