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  • Neumora Therapeutics halts lead depression drug after two more Phase 3 failures, plans 35% staff cuts
    Neumora Therapeutics announced that its lead depression candidate will be discontinued after it did not meet primary endpoints in two additional Phase 3 trials. The company said the data were consi…
    Endpoints · 2mo agoNegative readoutNegative↗ source
  • Lilly reports early positive results for new JAK2 inhibitor in hard-to-treat myelofibrosis
    Lilly has incorporated a JAK2‑targeting drug originally discovered by Ajax Therapeutics after its recent acquisition. The experimental pill is intended for patients with myelofibrosis, a difficult‑…
    BioPharma Dive · 2mo agoPositive readoutPositive↗ source
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  • Sanofi’s Tzield approved amid review dispute as Bicillin shortage hampers syphilis treatment
    An Arizona woman pregnant with syphilis could not receive timely treatment because of a worsening shortage of Bicillin, the injectable penicillin made by Pfizer. The shortage has raised concerns ab…
    STAT · 2mo agoRegulatoryNeutral↗ source
  • US sees 800% rise in congenital syphilis births amid penicillin shortage, officials warn of preventable "never event"
    The article notes a dramatic surge in congenital syphilis cases in the United States, with births affected rising about 800% between 2012 and 2024. This increase is described as a "never event" bec…
    STAT · 2mo agoNegative↗ source
  • Celiac disease faces new therapeutic possibilities as companies target underlying inflammation
    Celiac disease affects roughly one in every hundred people worldwide, imposing a daily burden that goes far beyond dietary restrictions. Currently, patients have no approved medicines and must rel…
    BioPharma Dive · 2mo agoPositive↗ source
  • HMNC Brain Health raises $50M Series B to advance two depression drugs
    HMNC Brain Health announced it has closed a $50 million Series B financing round. The capital will be used to move two depression drug candidates into mid-stage clinical trials. The round was led…
    Endpoints · 2mo agoDealNeutral↗ source
  • Pfizer fails to provide emergency penicillin donations as Trump administration seeks policy change to curb drugmaker price avoidance
    Pfizer has not complied with a request from state health agencies to donate emergency penicillin, a measure intended to act as a backstop against congenital syphilis. The shortfall underscores ong…
    STAT · 2mo agoRegulatoryNegative↗ source
  • Lilly showcases Jaypirca combination data in CLL at EHA26, debuting results from Ajax acquisition
    Eli Lilly highlighted new blood‑cancer data at the European Hematology Association meeting in Stockholm. The company presented early clinical results for its Jaypirca therapy combined with the stan…
    Endpoints · 2mo agoNeutral↗ source
  • Medicaid fraud crackdown threatens home care for disabled, risking loss of essential services
    States are adopting a Medicaid fraud enforcement strategy modeled on the Trump administration, tightening regulations and cutting funding that many disability advocates say will strain the home‑car…
    STAT · 2mo agoRegulatoryNegative↗ source
  • Strategic steps for moving sterile injectables from lab to clinical trials
    The article, sponsored by Vetter, discusses how drug owners of sterile injectable candidates face a key question when a molecule is ready for first‑in‑human studies: how fast can a clinical batch b…
    BioPharma Dive · 2mo agoPositive↗ source
  • South Asian American families often keep autism diagnoses hidden, delaying care
    Child and adolescent psychiatrist Ritu Goel points out that the CDC now estimates autism affects about one in 31 U.S. children, a rise from earlier figures. She observes that many South Asian Ameri…
    STAT · 2mo agoNegative↗ source
  • Six Biopharma Leaders Drive LGBTQ+ Inclusion Amid Rising Anti-LGBTQ Legislation
    Six executives are spearheading initiatives to improve LGBTQ+ inclusion across the biopharmaceutical sector. Their work focuses on creating supportive policies, training programs, and community out…
    Endpoints · 2mo agoNeutral↗ source
  • Pediatrician urges rigorous trials for AI tools used with children
    Dr. Dua Hassan, a pediatrician at Boston Children’s Hospital, writes an opinion piece about the growing use of artificial-intelligence applications in child care. She describes a typical office vi…
    STAT · 2mo agoNeutral↗ source
  • California law bans four harmful food additives, part of legislator Jesse Gabriel's push against ultra-processed foods
    California Assemblymember Jesse Gabriel has become a prominent figure in state food policy, championing measures aimed at reducing the health risks of ultra-processed foods. In 2023 he introduced…
    STAT · 2mo agoRegulatoryPositive↗ source
  • FDA approves Sanofi's teplizumab for children with stage 3 type 1 diabetes
    The FDA announced approval of teplizumab, a Sanofi developed therapy, for children aged 8 and older who have stage 3 type 1 diabetes. The decision came through the agency’s accelerated review path…
    STAT · 2mo agoApprovalPositive↗ source
  • WHO chief warns of worsening Ebola outbreak in DRC and Uganda after on-site visit
    The World Health Organization's director‑general said he is "really worried" after returning from a second trip to the Ebola‑affected regions of the Democratic Republic of the Congo and Uganda. He…
    STAT · 2mo agoNegative↗ source
  • Biopharma launches nominations for 2025 pay report and highlights Parabilis record IPO
    Endpoints Weekly announced the start of nominations for its eighth annual Women in Biopharma report, aiming to feature 20 distinguished women across science, leadership, and entrepreneurship. The…
    Endpoints · 2mo agoDealNeutral↗ source
  • 73-year-old woman begins medical residency, says she's all in
    In a recent First Opinion podcast, Dawn Zuidgeest-Craft, who is nearly 73, shared her decision to start a medical residency after completing medical school in her early seventies. The interview was…
    STAT · 2mo agoPositive↗ source
  • Merck's Welireg and Keytruda combo receives FDA approval for adjuvant kidney cancer therapy
    Merck announced that its combination of the oral VEGFR inhibitor Welireg and the immunotherapy Keytruda has been cleared by the U.S. Food and Drug Administration. The clearance applies to patients…
    Endpoints · 2mo agoApprovalPositive↗ source
  • GSK completes $10.6 billion acquisition of Nuvalent, the largest in its history
    GSK announced it has completed a $10.6 billion purchase of Nuvalent, marking the biggest deal the company has ever undertaken. The transaction was disclosed on Tuesday and values Nuvalent at $124…
    Endpoints · 2mo agoDealNeutral↗ source
  • Prometheus secures $12 billion to develop artificial general engineers as biotech deals surge
    Prometheus announced a $12 billion capital raise aimed at building what it calls “artificial general engineers,” a new class of AI tools for biopharma research and development. Nonprofit Blood Can…
    STAT · 2mo agoDealPositive↗ source
  • Trump administration proposes rule to close Medicare drug price-negotiation loophole
    The White House announced a proposal to tighten a policy that stops drugmakers from sidestepping Medicare price negotiations by adding new active ingredients to existing products. The change would…
    STAT · 2mo agoRegulatoryNeutral↗ source
  • Enliven Therapeutics raises $400M as Jazz's Zepzelca misses confirmatory trial
    Enliven Therapeutics, a biotech based in Burlingame, California, announced that it priced a public offering of its common stock that raised about $400 million. The capital raise follows the compan…
    Endpoints · 2mo agoDealNeutral↗ source
  • Novo's M&A head joins Forbion as Perrigo CEO steps down over conduct concerns
    Novo's senior M&A executive has left the company to take a role at Dutch investment firm Forbion. Forbion, which manages a portfolio of biotech companies, has been active in M&A and aims to increa…
    Endpoints · 2mo agoNeutral↗ source
  • Engaging Religious Leaders Key to Containing Ebola in DRC and Uganda
    An opinion piece by Olivia Wilkinson and Katherine Marshall stresses that Ebola spreads through caring acts such as tending the sick and handling burials, and that mistrust and misinformation often…
    STAT · 2mo agoPositive↗ source