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1,948 stories matching this filter · ← front page

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  • Dr McGregor on the DAD-IO Trial of Sacituzumab Govitecan and EV in Metastatic Urothelial Carcinoma
    Bradley McGregor, MD, discusses the background and design of the phase 1/2 DAD-IO trial in metastatic urothelial carcinoma.
    onclive · 6mo agoNeutral↗ source
  • Iopofosine I-131 shows high response rates and durable disease control in Waldenstrom macroglobulinemia trial
    The 12‑month follow‑up from the CLOVER‑WaM study reports that patients receiving Iopofosine I‑131 achieved strong clinical activity in Waldenstrom macroglobulinemia. In the per‑protocol group, the…
    onclive · 6mo agoPositive readoutPositive↗ source
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  • Expert outlines how to manage common skin and GI side effects of daraxonrasib in pancreatic cancer
    Dr Pant, MD, a professor at MD Anderson Cancer Center, discussed the safety profile of daraxonrasib, a RAS(ON) multi-selective inhibitor being studied in pancreatic ductal adenocarcinoma. The drug…
    onclive · 6mo agoNeutral↗ source
  • Pfizer CEO Albert Bourla rules out any transformative merger plans
    On the May 5, 2026 earnings call, Pfizer chief Albert Bourla was asked whether the company was considering a transformative merger in the near or medium term. Bourla answered that Pfizer has no pl…
    Endpoints · 6mo agoNeutral↗ source
  • BioNTech plans to cut up to 1,860 manufacturing jobs as it scales down production footprint
    BioNTech announced in its first‑quarter earnings release that it will reduce its manufacturing footprint. The company said the restructuring could affect as many as 1,860 employees working in its…
    Endpoints · 6mo agoLayoffsNegative↗ source
  • Pfizer halts final Trillium study, redirects R&D funds to cancer and obesity programs
    Pfizer announced it is ending the last clinical trial that originated from its 2021 purchase of Trillium Therapeutics. The company said the decision will free up cash that will be redirected to a…
    Endpoints · 6mo agoNeutral↗ source
  • Madrigal secures fourth MASH partnership, snapping up Arrowhead drug passed over by J&J
    Madrigal Pharmaceuticals announced its latest collaboration, marking the fourth deal focused on metabolic dysfunction-associated steatohepatitis (MASH) within a ten‑month span. The agreement bring…
    Endpoints · 6mo agoDealPositive↗ source
  • Emerging Antibody-Drug Conjugates Target New Endometrial Cancer Antigens Beyond HER2
    Faculty members highlighted a growing interest in endometrial cancer therapies that go beyond the HER2 pathway. They noted that the field is expanding its focus to a broader set of molecular target…
    onclive · 6mo agoPositive↗ source
  • Cytokinetics' HCM drug shows positive trial results, potentially doubling market after Bristol Myers' setback
    Cytokinetics announced that its oral therapy for hypertrophic cardiomyopathy (HCM) achieved positive results in a pivotal trial targeting a different form of the disease. The data suggest the drug…
    Endpoints · 6mo agoPositive readoutPositive↗ source
  • Expert discusses how clinicians choose between FOLFIRINOX and newly approved NALIRIFOX for metastatic pancreatic cancer
    Dr. Deirdre J. Cohen, director of GI Oncology at Mount Sinai, provides commentary on how doctors decide on frontline chemotherapy for metastatic pancreatic cancer. She notes that, as of 2026, ther…
    onclive · 6mo agoNeutral↗ source
  • Phase 1 trial of HS-10504 shows encouraging responses in EGFR C797S mutant lung cancer
    HS-10504, an investigational therapy, was evaluated in a Phase 1 study in patients with non-small cell lung cancer harboring the EGFR C797S mutation after progression on prior tyrosine kinase inhib…
    onclive · 6mo agoPositive readoutPositive↗ source
  • Microbiome startup Kanvas Biosciences secures $48 million to advance immunotherapy and malnutrition therapies
    Kanvas Biosciences announced it has closed a $48 million financing round to fund development of microbiome-based treatments targeting cancer immunotherapy response and severe malnutrition. The cap…
    Endpoints · 6mo agoDealPositive↗ source
  • J&J advances IBD combo to Phase 3 despite Phase 2 setbacks
    Johnson & Johnson said it will advance its experimental inflammatory bowel disease therapy, JNJ-4804, into Phase 3 trials even though the drug failed to meet primary endpoints in two Phase 2 studie…
    Endpoints · 6mo agoNegative readoutNeutral↗ source
  • Phase 3 STRIKE trial to assess disease-free survival of adjuvant tivozanib plus pembrolizumab in high-risk RCC
    Dr. Bradley McGregor, director of clinical research at the Lank Center of Genitourinary Oncology, outlined the key objectives of the ongoing phase 3 STRIKE trial (NCT06661720). The study evaluates…
    onclive · 6mo agoNeutral↗ source
  • Parsley Health joins nationwide insurance networks, expanding access to its primary-care model
    Parsley Health, a decade-old primary-care startup that originally operated on a cash-pay model, announced that it is now in-network with insurers across the United States. The move marks a shift f…
    Endpoints · 6mo agoPositive↗ source
  • Top Breast Cancer Experts Highlight Key Abstracts Ahead of 2026 ESMO Congress in Berlin
    Leading breast oncologists are sharing the abstracts they consider most important as the European Society for Medical Oncology (ESMO) Breast Cancer Congress approaches in Berlin from May 6 to 8, 20…
    onclive · 6mo agoNeutral↗ source
  • Takeda advances gene therapy, UK cancer biotech raises $83M, and new blood test may guide Wegovy use
    A Cleveland‑based biotech announced that a previously halted gene therapy program has been revived, offering a potential new option for patients as the company pursues additional studies. Takeda r…
    Endpoints · 6mo agoNeutral↗ source
  • Swiss pharma manufacturing remains steady despite tariff threats, impact may take years
    Swiss biotech day event highlighted that pharma manufacturing in Switzerland shows no immediate disruption from geopolitical tensions or potential tariffs. Industry representatives said that while…
    Endpoints · 6mo agoNeutral↗ source
  • Healthcare giants increasingly develop in-house AI tools instead of buying from startups
    Panelists at the Digital Healthcare Innovation Summit in Boston highlighted a growing shift among large health‑care organizations toward creating their own artificial‑intelligence solutions. Rather…
    Endpoints · 6mo agoNeutral↗ source
  • JAK inhibitor sequencing and transplant timing in myelofibrosis discussed at 2026 conference
    Dr. Andrew Kuykendall of Moffitt Cancer Center explained how doctors decide the order of JAK inhibitor therapies and when to consider allogeneic stem cell transplant for myelofibrosis patients. At…
    onclive · 6mo agoNeutral↗ source
  • Experts Highlight Emerging Strategies and Unmet Needs in Mantle Cell Lymphoma
    Dr. Lore Gruenbaum, PhD, recently discussed the evolving landscape of mantle cell lymphoma (MCL) in a presentation titled “New Understandings of Treatments, End Points, and Disease Biology Expand M…
    onclive · 6mo agoNeutral↗ source
  • Simlukafusp Alfa plus atezolizumab shows safety but no benefit over standard care in metastatic kidney cancer
    A clinical study evaluated the novel immunocytokine simlukafusp alfa combined with atezolizumab, with or without bevacizumab, in patients with unresectable metastatic renal cell carcinoma. The com…
    onclive · 6mo agoNegative readoutNeutral↗ source
  • Intercept’s next-generation FXR agonist INT-787 fails Phase 2 trial in alcohol-associated hepatitis
    Intercept Pharmaceuticals reported that its experimental FXR agonist INT-787 did not demonstrate efficacy in a Phase 2 study of patients with severe alcohol-associated hepatitis. The trial results…
    Endpoints · 6mo agoNegative readoutNegative↗ source
  • Study links specific dietary fats to pancreatic cancer risk, highlighting oleic acid as promoter and omega-3s as protective
    Researchers at Yale Cancer Center examined how different types of dietary fat affect pancreatic cancer development in a mouse model. Rather than focusing on total fat intake, the study compared twe…
    onclive · 6mo agoNeutral↗ source
  • Experts stress seamless coordination for relapsed multiple myeloma patients across academic and community clinics
    In a recent opinion segment, Dr. Ajay K. Nooka convened a discussion with Dr. Noopur S. Raje and Dr. Surbhi Sidana about how to best coordinate care for patients with relapsed and refractory multip…
    onclive · 6mo agoNeutral↗ source