the cliff
Patent cliff
Drugs ranked by the soonest barrier to generic / biosimilar entry. Each row shows the earliest-expiring patent OR FDA exclusivity for that drug — whichever falls first determines when competitive pressure begins.
- Feb 21, 20281.4yM-14Tofacitinib Citratetofacitinib citrateBiocon Pharma Ltd
- Feb 23, 20281.4ypatentSivextrotedizolid phosphate$MRKMerck & Co., Inc.
- Feb 25, 20281.4yODE-347Amondys 45casimersen$SRPTSarepta Therapeutics, Inc.
- Feb 26, 20281.4yODE-342Nulibryfosdenopterin hydrobromideSentynl Therapeutics Inc
- Mar 1, 20281.5ypatentAdqueydifamilastAcrotech Biopharma Inc
- Mar 3, 20281.5yODE-349Lorbrenalorlatinib$PFEPFIZER INC
- Mar 9, 20281.5yNCEZavzpretzavegepant hydrochloride$PFEPFIZER INC
- Mar 10, 20281.5yNCEDaybuetrofinetide$ACADACADIA PHARMACEUTICALS INC
- Mar 12, 20281.5ypatentCaplytalumateperone tosylateIntra-Cellular Therapies Inc
- Mar 19, 20281.5ypatentXenletalefamulin acetateNabriva Therapeutics US Inc
- Mar 21, 20281.5ypatentHarvoni(ledipasvir + sofosbuvir)$GILDGILEAD SCIENCES, INC.
- Mar 21, 20281.5ypatentVosevi(sofosbuvir + velpatasvir + voxilaprevir)$GILDGILEAD SCIENCES, INC.
- Mar 22, 20281.5ypatentLEUPROLIDE ACETATELEUPROLIDE ACETATE$AMRXAmneal Pharmaceuticals, Inc.
- Mar 22, 20281.5yGAINRezzayorezafungin acetateNapp Pharmaceuticals Ltd
- Mar 24, 20281.5yNCEJoenjaleniolisib [INN]Pharming Group NV
- Mar 26, 20281.5ypatentEdarbyclor(azilsartan medoxomil + chlorthalidone)Azurity Pharmaceuticals Inc
- Mar 26, 20281.5ypatentEdarbiazilsartan kamedoxomilAzurity Pharmaceuticals Inc
- Mar 27, 20281.5ypatentKetotifen Fumarateketotifen fumarateSentiss Pharmaceuticals LLC
- Mar 27, 20281.5yNCERivflozanedosiran sodiumNovo Nordisk AS
- Mar 28, 20281.5ypatentBysantimilsaperidone$VNDAVanda Pharmaceuticals Inc.
- Mar 30, 20281.5ypatentMonistat 7miconazole nitrateInsight Pharmaceuticals LLC
- Apr 7, 20281.6yNPPOzurdexdexamethasone$ABBVAbbVie Inc.
- Apr 25, 20281.6yNCEQalsodytofersen sodium$BIIBBIOGEN INC.
- Apr 26, 20281.6ypatentPramipexole Dihydrochloridepramipexole dihydrochlorideShasun USA Inc
- Apr 30, 20281.6yNPMigranaldihydroergotamine mesylateBausch Health US LLC
- Apr 30, 20281.6yODE-417FerriproxdeferiproneChiesi USA Inc
- Apr 30, 20281.6ypatentNicorettenicotine [USP]NAL Pharmaceuticals Ltd
- May 1, 20281.6ypatentClozarilclozapineHeritage Health Systems Inc
- May 2, 20281.6ypatentUpneeqoxymetazoline hydrochlorideRVL Pharmaceuticals Inc
- May 4, 20281.6ypatentInpefasotagliflozin$LXRXLEXICON PHARMACEUTICALS, INC.
- May 7, 20281.6ypatentCalcipotriene PrascocalcipotrienePrasco LLC
- May 9, 20281.6ypatentAddyiflibanserinSprout2 Inc
- May 9, 20281.6ypatentFruzaqlafruquintinibTakeda Pharmaceuticals USA Inc
- May 12, 20281.7yNCEVeozahfezolinetantAstellas Pharma US Inc
- May 15, 20281.7ypatentZerbaxa(ceftolozane sulfate + tazobactam sodium)$MRKMerck & Co., Inc.
- May 18, 20281.7yNCEMieboperfluorohexyloctane$BLCOBausch & Lomb Corp
- May 23, 20281.7ypatentDalvancedalbavancinAllergan Sales LLC
- May 28, 20281.7yODE-353infigratinib phosphateQED Therapeutics Inc
- May 30, 20281.7ypatentEnvarsus XRtacrolimusVeloxis Pharmaceuticals Inc
- Jun 3, 20281.7yI-971NubeqadarolutamideBayer HealthCare Pharmaceuticals Inc
- Jun 3, 20281.7ypatentNuplazidpimavanserin tartrate$ACADACADIA PHARMACEUTICALS INC
- Jun 3, 20281.7ypatentDoralquazepamGALT Pharmaceuticals LLC
- Jun 4, 20281.7ypatentAzelastine Hydrochloride Wallaceazelastine hydrochlorideWallace Pharmaceuticals Inc
- Jun 4, 20281.7yODE-354TembexabrincidofovirSymBio Pharmaceuticals Ltd
- Jun 5, 20281.7yNPWidaplik(amlodipine besylate + indapamide + telmisartan)Azurity Pharmaceuticals Inc
- Jun 11, 20281.7yM-14DoxercalciferoldoxercalciferolHospira Inc
- Jun 17, 20281.8yI-984POSACONAZOLEPOSACONAZOLEPar Sterile Products LLC
- Jun 19, 20281.8ypatentCardamystetripamil$MISTMilestone Pharmaceuticals Inc.
- Jun 20, 20281.8yM-316Descovy(emtricitabine + tenofovir alafenamide)$GILDGILEAD SCIENCES, INC.
- Jun 23, 20281.8yNCELitfuloritlecitinib [INN]$PFEPFIZER INC
sourced from FDA Orange Book · approved drugs only · biologics + biosimilars excluded (those live in the Purple Book — coming soon)