the cliff
Patent cliff
Drugs ranked by the soonest barrier to generic / biosimilar entry. Each row shows the earliest-expiring patent OR FDA exclusivity for that drug — whichever falls first determines when competitive pressure begins.
- Apr 30, 20281.5ypatentNicorettenicotine [USP]NAL Pharmaceuticals Ltd
- May 1, 20281.5ypatentClozarilclozapineHeritage Health Systems Inc
- May 2, 20281.5ypatentUpneeqoxymetazoline hydrochlorideRVL Pharmaceuticals Inc
- May 4, 20281.5ypatentInpefasotagliflozin$LXRXLEXICON PHARMACEUTICALS, INC.
- May 7, 20281.5ypatentCalcipotriene PrascocalcipotrienePrasco LLC
- May 9, 20281.5ypatentAddyiflibanserinSprout2 Inc
- May 9, 20281.5ypatentFruzaqlafruquintinibTakeda Pharmaceuticals USA Inc
- May 12, 20281.5yNCEVeozahfezolinetantAstellas Pharma US Inc
- May 15, 20281.5ypatentZerbaxa(ceftolozane sulfate + tazobactam sodium)$MRKMerck & Co., Inc.
- May 18, 20281.5yNCEMieboperfluorohexyloctane$BLCOBausch & Lomb Corp
- May 23, 20281.6ypatentDalvancedalbavancinAllergan Sales LLC
- May 28, 20281.6yODE-353infigratinib phosphateQED Therapeutics Inc
- May 30, 20281.6ypatentEnvarsus XRtacrolimusVeloxis Pharmaceuticals Inc
- Jun 3, 20281.6yI-971NubeqadarolutamideBayer HealthCare Pharmaceuticals Inc
- Jun 3, 20281.6ypatentNuplazidpimavanserin tartrate$ACADACADIA PHARMACEUTICALS INC
- Jun 3, 20281.6ypatentDoralquazepamGALT Pharmaceuticals LLC
- Jun 4, 20281.6ypatentAzelastine Hydrochloride Wallaceazelastine hydrochlorideWallace Pharmaceuticals Inc
- Jun 4, 20281.6yODE-354TembexabrincidofovirSymBio Pharmaceuticals Ltd
- Jun 5, 20281.6yNPWidaplik(amlodipine besylate + indapamide + telmisartan)Azurity Pharmaceuticals Inc
- Jun 10, 20281.6yI-967Mavyret(glecaprevir + pibrentasvir)$ABBVAbbVie Inc.
- Jun 11, 20281.6yM-14DoxercalciferoldoxercalciferolHospira Inc
- Jun 17, 20281.6yI-984POSACONAZOLEPOSACONAZOLEPar Sterile Products LLC
- Jun 19, 20281.6ypatentCardamystetripamil$MISTMilestone Pharmaceuticals Inc.
- Jun 20, 20281.6yM-316Descovy(emtricitabine + tenofovir alafenamide)$GILDGILEAD SCIENCES, INC.
- Jun 23, 20281.6yNCELitfuloritlecitinib [INN]$PFEPFIZER INC
- Jun 25, 20281.7yGAINZemdriplazomicin sulfateCipla USA Inc
- Jun 27, 20281.7ypatentKazano(alogliptin benzoate + metformin hydrochloride)Takeda Pharmaceuticals USA Inc
- Jun 27, 20281.7ypatentOseni(alogliptin benzoate + pioglitazone hydrochloride)Takeda Pharmaceuticals USA Inc
- Jun 27, 20281.7ypatentAlogliptin Benzoate Perrigoalogliptin benzoatePerrigo New York Inc
- Jun 29, 20281.7ypatentDaurismoglasdegib$PFEPFIZER INC
- Jul 1, 20281.7ypatentEVEROLIMUSEVEROLIMUSNovugen Pharma (Malaysia) Sdn Bhd
- Jul 7, 20281.7ypatentViberzieluxadoline$ABBVAbbVie Inc.
- Jul 8, 20281.7ypatentRozlytrekentrectinibF. Hoffmann-La Roche Ltd
- Jul 9, 20281.7ypatentOsphenaospemifeneDuchesnay USA Inc
- Jul 10, 20281.7ypatentTwirla(ethinylestradiol + levonorgestrel)Agile Therapeutics Inc
- Jul 10, 20281.7yM-14PRUCALOPRIDE SUCCINATEPRUCALOPRIDE SUCCINATESpecGx LLC
- Jul 10, 20281.7ypatentEstradiol NovenestradiolNoven Pharmaceuticals Inc
- Jul 11, 20281.7yI-970KerendiafinerenoneBayer AG
- Jul 15, 20281.7ypatentFlonase Sensimistfluticasone furoateGlaxoSmithKline LLC
- Jul 16, 20281.7yODE-362Rezurockbelumosudil mesylateKadmon Pharmaceuticals LLC
- Jul 16, 20281.7yODE-359FexinidazolefexinidazoleSanofi-Aventis US LLC
- Jul 20, 20281.7yODE-363BylvayodevixibatIpsen SA
- Jul 21, 20281.7yNCEYcanthcantharidin$VRCAVerrica Pharmaceuticals Inc.
- Jul 24, 20281.7yNCEXdemvylotilaner$TARSTarsus Pharmaceuticals, Inc.
- Jul 27, 20281.7ypatentBivalirudinbivalirudinAvenacy Inc
- Jul 29, 20281.7ypatentMulpletalusutrombopag$SGIOFSHIONOGI & CO LTD
- Aug 6, 20281.8ypatentDronabinoldronabinolVertanical GmbH
- Aug 7, 20281.8ypatentIntrarosaprasteroneCosette Pharmaceuticals Inc
- Aug 8, 20281.8ypatentCaprelsavandetanibGenzyme Corp
- Aug 10, 20281.8ypatentSeysarasarecycline hydrochlorideAlmirall SA
sourced from FDA Orange Book · approved drugs only · biologics + biosimilars excluded (those live in the Purple Book — coming soon)