the cliff
Patent cliff
Drugs ranked by the soonest barrier to generic / biosimilar entry. Each row shows the earliest-expiring patent OR FDA exclusivity for that drug — whichever falls first determines when competitive pressure begins.
- Jan 3, 20281.5ypatentEFINACONAZOLEEFINACONAZOLEOrtho Dermatologics Inc
- Jan 7, 20281.5ypatentTrabectedintrabectedin$JNJJOHNSON & JOHNSON
- Jan 9, 20281.5ypatentActonelrisedronate sodiumAllergan Finance LLC
- Jan 15, 20281.5ypatentNextstellis(drospirenone + estetrol)Mayne Pharma USA Inc
- Jan 16, 20281.5yI-962Lumakrassotorasib$AMGNAMGEN INC
- Jan 18, 20281.5ypatentNayzilammidazolam [INN]UCB SA
- Jan 20, 20281.5yNCEBrenzavvybexagliflozinTheracosBio LLC
- Jan 22, 20281.5ypatentGocovriamantadine hydrochlorideAdamas Pharmaceuticals Inc
- Jan 22, 20281.5yODE-345Carbaglucarglumic acidRecordati Rare Diseases Inc
- Jan 27, 20281.5yI-981JaypircapirtobrutinibEli Lilly and Co
- Jan 28, 20281.6ypatentRaltegravirraltegravir potassiumLupin Ltd
- Jan 30, 20281.6ypatentNatazia(dienogest + estradiol valerate)Bayer HealthCare Pharmaceuticals Inc
- Jan 30, 20281.6yNPSymbravo(meloxicam + rizatriptan benzoate)$AXSMAxsome Therapeutics, Inc.
- Jan 30, 20281.6ypatentTrulanceplecanatideSalix Pharmaceuticals Ltd
- Jan 31, 20281.6yD-195PAXLOVID (COPACKAGED)NIRMATRELVIR$PFEPFIZER INC
- Feb 1, 20281.6ypatentAlvescociclesonideCovis Pharmaceuticals Inc (Inactive)
- Feb 2, 20281.6ypatentMETRONIDAZOLEMETRONIDAZOLESaptalis Pharmaceuticals LLC
- Feb 3, 20281.6ypatentTwyneo(benzoyl peroxide + tretinoin)Mayne Pharma USA Inc
- Feb 3, 20281.6ypatentDOXYCYCLINE HYCLATEDOXYCYCLINE HYCLATE$AMRXAmneal Pharmaceuticals, Inc.
- Feb 3, 20281.6yNPApomorphine Hydrochlorideapomorphine hydrochlorideTruPharma LLC
- Feb 3, 20281.6ypatentEpsolaybenzoyl peroxideGalderma Laboratories LP
- Feb 3, 20281.6yODE-325Tepmetkotepotinib hydrochlorideEMD Serono Inc
- Feb 5, 20281.6ypatentZOLEDRONIC ACIDZOLEDRONIC ACIDAvenacy Inc
- Feb 7, 20281.6ypatentDimethyl Fumaratedimethyl fumarateSOLA Pharmaceuticals Inc
- Feb 7, 20281.6yNPPMoxidectinmoxidectinAtticus Medical Pty Ltd
- Feb 17, 20281.6ypatentReyvowlasmiditanEli Lilly and Co
- Feb 17, 20281.6yNCEFilsparisparsentan$TVTXTravere Therapeutics, Inc.
- Feb 21, 20281.6yNPChenodalchenodiol$MIRMMirum Pharmaceuticals, Inc.
- Feb 21, 20281.6yM-14Tofacitinib Citratetofacitinib citrateBiocon Pharma Ltd
- Feb 23, 20281.6ypatentSivextrotedizolid phosphate$MRKMerck & Co., Inc.
- Feb 25, 20281.6yODE-347Amondys 45casimersen$SRPTSarepta Therapeutics, Inc.
- Feb 26, 20281.6yODE-342Nulibryfosdenopterin hydrobromideSentynl Therapeutics Inc
- Mar 1, 20281.6ypatentAdqueydifamilastAcrotech Biopharma Inc
- Mar 3, 20281.6yODE-349Lorbrenalorlatinib$PFEPFIZER INC
- Mar 9, 20281.7yNCEZavzpretzavegepant hydrochloride$PFEPFIZER INC
- Mar 10, 20281.7yNCEDaybuetrofinetide$ACADACADIA PHARMACEUTICALS INC
- Mar 12, 20281.7ypatentCaplytalumateperone tosylateIntra-Cellular Therapies Inc
- Mar 19, 20281.7ypatentXenletalefamulin acetateNabriva Therapeutics US Inc
- Mar 21, 20281.7ypatentVosevi(sofosbuvir + velpatasvir + voxilaprevir)$GILDGILEAD SCIENCES, INC.
- Mar 22, 20281.7ypatentLEUPROLIDE ACETATELEUPROLIDE ACETATE$AMRXAmneal Pharmaceuticals, Inc.
- Mar 22, 20281.7yGAINRezzayorezafungin acetateNapp Pharmaceuticals Ltd
- Mar 24, 20281.7yNCEJoenjaleniolisib [INN]Pharming Group NV
- Mar 26, 20281.7ypatentEdarbyclor(azilsartan medoxomil + chlorthalidone)Azurity Pharmaceuticals Inc
- Mar 26, 20281.7ypatentEdarbiazilsartan kamedoxomilAzurity Pharmaceuticals Inc
- Mar 27, 20281.7ypatentKetotifen Fumarateketotifen fumarateSentiss Pharmaceuticals LLC
- Mar 27, 20281.7yNCERivflozanedosiran sodiumNovo Nordisk AS
- Mar 28, 20281.7ypatentBysantimilsaperidone$VNDAVanda Pharmaceuticals Inc.
- Mar 30, 20281.7ypatentMonistat 7miconazole nitrateInsight Pharmaceuticals LLC
- Apr 7, 20281.7yNPPOzurdexdexamethasone$ABBVAbbVie Inc.
- Apr 25, 20281.8yNCEQalsodytofersen sodium$BIIBBIOGEN INC.
sourced from FDA Orange Book · approved drugs only · biologics + biosimilars excluded (those live in the Purple Book — coming soon)