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  • CLL-321 Trial Efficacy and Safety Results Analysis
    Phase 3 results: pirtobrutinib boosts PFS, delays next treatment after prior BTK therapy, and shows low cardiac toxicity.
    onclive · 2mo ago↗ source
  • #ASGCT26: Tessera reveals strongest data yet for in vivo sickle cell therapy
    BOSTON — Tessera Therapeutics has created an experimental gene editing drug for sickle cell disease that could compete with commercial cell therapies but is delivered as an infusion — no complex ce…
    Endpoints · 2mo ago↗ source
  • How Reimagined Research Endeavors Intersect With Dignified End-of-Life Care: With D. Ross Camidge, MD, PhD; and Charles D. Blanke, MD, FACP, FASCO
    Drs Camidge and Blanke discuss Dr Blanke's career path from pioneering targeted cancer therapies to becoming a leading advocate for medical aid in dying.
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onclive · 2mo ago
↗ source
  • BRUIN CLL-321 Trial Impact and Treatment Selection
    Experts outline relapse workup in CLL, using PET-CT and biopsy for suspected Richter’s, plus resistance and TP53 testing to guide next therapy.
    onclive · 2mo ago↗ source
  • Biomarker-Driven Treatment Decisions and Managing Progression After Frontline Immunotherapy
    Upfront biomarker testing reshapes endometrial cancer care, guiding targeted and immune therapy—and exposing gaps in second-line options.
    onclive · 2mo ago↗ source
  • Extreme heat is worsening faster for Black Americans
    Bill Cassidy's can't-win conundrum, what RFK Jr. gets right and wrong about antidepressants, and more health news
    STAT · 2mo ago↗ source
  • Merck KGaA's clients are stockpiling due to Iran war, supporting guidance boost
    Merck KGaA appears to have a big-picture view of how the Iran war is affecting the pharma industry so far. The German company is seeing an uptick in demand for its lab equipment products as ...
    Endpoints · 2mo ago↗ source
  • STAT+: Drug meant to make gene therapy safer may also make it less effective
    Encoded Therapeutics gives a heads-up to other gene therapy company about the trade-offs with a drug meant to improve safety.
    STAT · 2mo ago↗ source
  • STAT+: Scientists link boy’s tumor to gene therapy viruses, in rare finding
    Doctors have linked a boy's tumor to a gene therapy, but say the rare risks need to be weighed against the profound benefits such medicines can offer.
    STAT · 2mo ago↗ source
  • STAT+: A new kind of liver crisis is emerging in the U.S. The American diet is to blame
    Young people and women are particularly vulnerable to MetALD, a dangerous merging of metabolic disease and alcohol use.
    STAT · 2mo ago↗ source
  • STAT+: Bill Cassidy risked his legacy. It may not be enough to save his career
    Sen. Bill Cassidy risked his legacy. It may not be enough to save his career.
    STAT · 2mo ago↗ source
  • Opinion: Access to air conditioning is critical preventive care. But federal policy treats it as optional
    Access to air conditioning is critical preventive care. But federal policy treats it as optional, write Charles E. Leonard and Anthony Nicome.
    STAT · 2mo ago↗ source
  • Opinion: What can ‘blue zones’ really teach us about aging?
    Have you heard about blue zones where people tend to live much longer? They’re more complicated than they might sound.
    STAT · 2mo ago↗ source
  • Opinion: RFK Jr.’s antidepressant deprescribing push gets one thing right — and others dangerously wrong
    “Deprescribing requires gradual tapering, psychological support, careful risk stratification, and accessible alternatives — none of which Kennedy’s initiative provides at scale.”
    STAT · 2mo ago↗ source
  • Dr McCann on the FDA Approval of Vepdegestrant for ESR1-Mutated, ER+ Advanced Breast Cancer
    Kelly Elizabeth McCann, MD, PhD, notes the role of vepdegestrant in the ESR1-mutated, ER-positive, HER2-negative advanced breast cancer treatment paradigm.
    onclive · 2mo ago↗ source
  • Honesty and Humor Provide Hope in Breast Cancer Survivorship: With Sara Nunnery, MD, MSCI; and Annie Bond
    Dr Nunnery and Annie Bond discuss breast cancer survivorship and patient advocacy.
    onclive · 2mo ago↗ source
  • Lilly points to low-dose Zepbound and Foundayo as weight loss maintenance options
    Reducing the dose of Eli Lilly’s obesity shot Zepbound could provide a safe, effective and potentially cheaper option for the maintenance of weight loss, according to new data. The findings come fr…
    Endpoints · 2mo ago↗ source
  • AUA and SUO Amend Advanced Prostate Cancer Guideline
    The AUA and SUO released the 2026 amendment to the Advanced Prostate Cancer Guideline.
    onclive · 2mo ago↗ source
  • STAT+: Why Marty Makary was the worst FDA commissioner in 25 years
    Marty Makary, who resigned under pressure from the FDA, brought to the job a fundamental lack of understanding of the nature of the role, STAT's Matthew Herper writes.
    STAT · 2mo ago↗ source
  • Dr Postow on an Ideal Post-ICI Monitoring Framework in Melanoma
    Michael A. Postow, MD, discusses the importance of long-term multidisciplinary follow-up for patients with melanoma treated with ICIs.
    onclive · 2mo ago↗ source
  • Dr Postow on the Timing of Delayed or Re-Emergent irAEs in Melanoma
    Michael A. Postow, MD, discusses the evolving understanding of ICIs in melanoma and the unique toxicity profiles associated with these agents.
    onclive · 2mo ago↗ source
  • Males who discuss suicide seek help less often than females, report finds
    Out of 1.5 million messages received in 2025, the Crisis Text Line found that less then 20% of the texters identified as male only
    STAT · 2mo ago↗ source
  • STAT+: European Union inks a draft deal to boost local production of medicines and avoid shortages
    The E.U. reached a provisional deal to strengthen the supply of essential medicines and avoid shortages by ‌boosting domestic production and reducing reliance on imports.
    STAT · 2mo ago↗ source
  • EU reaches provisional deal on Critical Medicines Act
    The Critical Medicines Act reached its next milestone on Tuesday, after the European Parliament and the Council provisionally voted it through. The proposed regulation aims to improve the European…
    Endpoints · 2mo ago↗ source
  • STAT+: Makary departs FDA amid turmoil as Diamantas, agency’s top food official, steps in
    Food and Drug Administration Commissioner Marty Makary is resigning from his role after a tumultuous tenure.
    STAT · 2mo ago↗ source