<![CDATA[Biomarker-Driven Treatment Decisions and Managing Progression After Frontline Immunotherapy]]>

Advertisement Opinion|Videos|May 13, 2026 Biomarker-Driven Treatment Decisions and Managing Progression After Frontline Immunotherapy Author(s)Robert M. Wenham, MD, Premal H. Thaker, MD, MS, Tiffany Redfern, MD, FACOG Upfront biomarker testing reshapes endometrial cancer care, guiding targeted and immune therapy—and exposing gaps in second-line options. Advertisement Episodes in this seriesEP. 1 The Endometrial Cancer Treatment LandscapeEP. 2 RUBY Trial Design, Efficacy, and Real-World Evidence for Dostarlimab EP. 3 Four-Year Follow-Up Outcomes in dMMR Endometrial Cancer Presented at SGO 2026EP. 4 Comparing Approved Checkpoint Inhibitor Regimens and Optimal Treatment DurationNow PlayingEP. 5 Biomarker-Driven Treatment Decisions and Managing Progression After Frontline ImmunotherapyEP. 6 Emerging Clinical Trials and Future Therapeutic Strategies in Recurrent Endometrial Cancer The panel transitions to biomarker testing and treatment sequencing in patients who progress after frontline immunotherapy. Dr. Redfern describes her standardized approach to upfront immunohistochemistry testing across all endometrial cancer patients regardless of histology, emphasizing the value of consistency to avoid testing gaps and treatment delays. Dr. Konecny outlines the evolution from a histology-based framework to a molecularly driven approach encompassing mismatch repair status, p53 mutation, HER2 amplification, and hormone receptor expression. The panel then addresses the unmet need for patients who progress on frontline checkpoint inhibitor therapy—particularly those with mismatch repair–proficient disease—and discusses off-label use of lenvatinib plus pembrolizumab in this setting. Dr. Thaker notes that available approved options remain limited for checkpoint inhibitor–exposed patients, underscoring the urgency of clinical trial enrollment and the potential of emerging agents including antibody-drug conjugates. NewsletterStay up to date on the most recent and practice-changing oncology dataSubscribe Now! Advertisement Related ContentAdvertisementFuture Directions in Metastatic Castration-Resistant Prostate CancerByPedro C. 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