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  • GSK goes to China for $1B siRNA deal in Arrowhead's obesity lane
    GSK is further delving into the cardiometabolic space — and deepening its relationship with China biotechs — in a $1 billion biobucks deal with an siRNA startup. The UK pharma is teaming with Suz…
    Endpoints · 2mo ago↗ source
  • <![CDATA[Consensus Viewpoints Offer Guidance in Rapidly Evolving Multiple Myeloma Management]]>
    <![CDATA[Ajai Chari, MD, outlines key consensus viewpoints and recommendations for multiple myeloma management from Bridging the Gaps 2025.]]>
    onclive · 2mo ago↗ source
  • <![CDATA[Comparing Approved Checkpoint Inhibitor Regimens and Optimal Treatment Duration]]>
    <![CDATA[New SGO 2026 data shows frontline checkpoint inhibitors deliver 4-year survival gains and near-zero relapse after two years in DMMR cancers.]]>
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onclive · 2mo ago
↗ source
  • <![CDATA[Disease Assessment and Mutational Testing in Progressive CLL]]>
    <![CDATA[Experts discuss relapsed CLL workup, using PET-CT and lymph node biopsy to rule out Richter’s, plus resistance testing to guide next therapy.]]>
    onclive · 2mo ago↗ source
  • <![CDATA[Clinical Scenario Presentation and Treatment Approach for Progressive Disease]]>
    <![CDATA[Experts weigh mutation testing, comorbidities, and patient preference to guide second-line CLL options after BTK inhibitor resistance.]]>
    onclive · 2mo ago↗ source
  • <![CDATA[Dr Pant on the Mechanism of Action of Daraxonrasib in PDAC]]>
    <![CDATA[Shubham Pant, MD, MBBS, explains the unique "on-state" binding mechanism of daraxonrasib.]]>
    onclive · 2mo ago↗ source
  • <![CDATA[Four-Year Follow-Up Outcomes in dMMR Endometrial Cancer Presented at SGO 2026]]>
    <![CDATA[SGO 2026 data shows frontline checkpoint inhibitors in dMMR gynecologic cancer drive flat survival curves, hinting at cure and less chemo.]]>
    onclive · 2mo ago↗ source
  • CellCentric raises $220M to get multiple myeloma pill to market
    CellCentric has reeled in a massive fund to help it address multiple myeloma patients who have exhausted all other treatment options. The 22-year-old transatlantic biotech has collected a $220 mi…
    Endpoints · 2mo ago↗ source
  • Bayer to buy Perfuse Therapeutics for $300M upfront
    Bayer is committing $300 million upfront to buy ophthalmology biotech Perfuse Therapeutics and its mid-stage program targeting the leading causes of blindness. The deal appears to be Bayer’s firs…
    Endpoints · 2mo ago↗ source
  • Novo Nordisk's Q1 in four words: Pills, pricing, payments and pressure
    A million patients with obesity are already taking Novo Nordisk’s Wegovy pill, CEO Mike Doustdar said Wednesday, despite the market entry of Lilly’s Foundayo. Novo's pill had sales of 2.3 billion…
    Endpoints · 2mo ago↗ source
  • <![CDATA[Simlukafusp Alfa Regimens Show Manageable Safety and Activity But Do Not Outperform SOC in Metastatic RCC]]>
    <![CDATA[Simlukafusp alfa plus atezolizumab with/without bevacizumab was safe and active but did not improve upon responses with SOC treatments in metastatic RCC.]]>
    onclive · 2mo ago↗ source
  • <![CDATA[Dr Cohen on Frontline Chemotherapy Selection in Metastatic Pancreatic Cancer ]]>
    <![CDATA[Deirdre J. Cohen, MD, MS, discusses clinical decision-making and the comparative efficacy of FOLFIRINOX and NALIRIFOX in metastatic pancreatic cancer.]]>
    onclive · 2mo ago↗ source
  • <![CDATA[Dr Pant on Managing Toxicities With Daraxonrasib in PDAC]]>
    <![CDATA[Shubham Pant, MD, MBBS, discusses the management of dermatologic and GI toxicities associated with the RAS(ON) inhibitor daraxonrasib.]]>
    onclive · 2mo ago↗ source
  • Intercept's next-gen FXR agonist fails Phase 2 in latest setback for Italian-owned pharma
    Intercept Pharmaceuticals' attempt at creating a next-generation FXR agonist for certain forms of liver inflammation appears to have ended. The drug developer's INT-787 showed "no clear evidence…
    Endpoints · 2mo ago↗ source
  • Pfizer's Albert Bourla says he has no mega-merger plans
    The most candid man in pharma strikes again. When asked on Tuesday’s earnings call whether Pfizer would consider a “transformative M&A” deal in the near or medium term, CEO Albert Bourla said…
    Endpoints · 2mo ago↗ source
  • <![CDATA[HS-10504 Shows Promising Activity in EGFR C797S–Mutant NSCLC After TKI Resistance]]>
    <![CDATA[Phase 1 data show HS-10504 yields encouraging responses and manageable safety in EGFR C797S–mutant NSCLC post TKI therapy.]]>
    onclive · 2mo ago↗ source
  • BioNTech to scale down manufacturing, over 1,800 jobs on the line
    BioNTech is making big cuts to its manufacturing footprint. The German company said in its first-quarter earnings release that up to 1,860 manufacturing staff could be impacted by its planned dow…
    Endpoints · 2mo ago↗ source
  • Parsley Health goes in-network nationwide
    When I first heard about Parsley Health close to a decade ago, the startup embodied a few trends I was following closely: primary care startups and cash-pay healthcare. For a ...
    Endpoints · 2mo ago↗ source
  • <![CDATA[Breast Cancer Experts Preview Abstracts to Watch at the 2026 ESMO Breast Cancer Congress]]>
    <![CDATA[Experts in a range of breast cancer subtypes highlight research data being presented at the 2026 ESMO Breast Cancer Congress.]]>
    onclive · 2mo ago↗ source
  • <![CDATA[The Type of Fat—Not the Amount—Fuels Pancreatic Cancer]]>
    <![CDATA[Research from Yale Cancer Center showed that the type of fat consumed may matter more than amount in pancreatic cancer.]]>
    onclive · 2mo ago↗ source
  • Second life for gene therapy; Takeda Phase 2/3 win; UK cancer biotech's $83M
    A blood test might predict who will respond to Wegovy; Viridian's thyroid eye disease drug wins another Phase 3; Ideaya drops two GSK-returned assets. 🧬 Second life for a gene therapy: A Clevela…
    Endpoints · 2mo ago↗ source
  • Swiss manufacturing, biotech industry so far unfazed by geopolitics
    BASEL, Switzerland — Pharma manufacturing in Switzerland appears to be unperturbed by the threat of tariffs, but it might take several years before the impact of companies moving production to the…
    Endpoints · 2mo ago↗ source
  • Pfizer ends Trillium-related development as R&D spend jumps
    Pfizer has discontinued the final clinical study stemming from its 2021 acquisition of Trillium Therapeutics, funneling cash primarily toward a host of other cancer and obesity studies. The compa…
    Endpoints · 2mo ago↗ source
  • Microbiome startup raises $48M for immunotherapy and malnutrition treatments
    Scientists trying to understand why cancer immunotherapy works so well for some patients and not others have found a potential answer in one cancer survivor's poop. A biotech startup has studied t…
    Endpoints · 2mo ago↗ source
  • J&J's IBD combo fails Phase 2 studies, but will move into pivotal testing
    Johnson & Johnson will move a treatment for inflammatory bowel disease into Phase 3 studies despite the therapy's failure in two mid-stage trials. The company said that JNJ-4804, a combinatio…
    Endpoints · 2mo ago↗ source