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  • #ASCO26: AstraZeneca's triplet combo succeeds in liver cancer subgroup
    CHICAGO — AstraZeneca on Monday reported data from a new study showing the combination of a targeted treatment and two immunotherapies can benefit patients with certain kinds of liver cancer. Ind…
    Endpoints · 1mo ago↗ source
  • Lilly licenses GLP-2 asset from Korean biotech Hanmi for $75M upfront
    Eli Lilly, which has made billions off the success of its GLP-1 drugs, is now making a play for GLP-2s through a licensing deal with Hanmi. The Indianapolis drugmaker will pay $75 million upfront…
    Endpoints · 1mo ago↗ source
  • #ASCO26: Erleada succeeds in early-stage prostate cancer study, but questions remain
    CHICAGO — As part of a hormone therapy regimen for prostate cancer, J&J’s Erleada cut the risk of metastasis or death by 20% when given around surgery, researchers reported Sunday. Treatment…
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Endpoints · 1mo ago
↗ source
  • Oculis’ eye drops for diabetic macular edema flunk Phase 3 test
    Oculis saw its stock plummet after reporting that its investigational eye drops for diabetic macular edema (DME) did not succeed in a pair of Phase 3 trials. After a year, its eye drop called OCS…
    Endpoints · 1mo ago↗ source
  • #ASCO26: Yes, Revolution Medicines' pancreatic cancer data are that good
    CHICAGO — When oncologist Brian Wolpin saw the positive results from Revolution Medicines' pivotal pancreatic cancer study for the first time, he was rendered speechless, he told Endpoints News.…
    Endpoints · 1mo ago↗ source
  • #ASCO26: Summit, Akeso drug reduces death by 34% in China lung cancer study
    CHICAGO — The leading drug in biopharma's hottest immunotherapy race reduced the risk of death by 34% in previously untreated Chinese lung cancer patients, compared to standard immunotherapy plus c…
    Endpoints · 1mo ago↗ source
  • #ASCO26: Personalized cancer vaccines may help brain cancer patients live longer
    Personalized cancer vaccines might make notoriously deadly brain cancers more susceptible to immunotherapy and possibly prolong survival for some patients, according to new research from the Dana-F…
    Endpoints · 1mo ago↗ source
  • #ASCO26: Grail’s cancer blood test isn’t ready for widespread use, experts say
    CHICAGO — Grail's blood test, which it has pitched as a way to spot a variety of cancers early in their growth, still isn't ready to be used as a regular screening tool, experts not involved ...
    Endpoints · 1mo ago↗ source
  • Can AI do scientific research?; The 'magic bullet' search has faded in immunotherapy; and more
    Welcome back to Endpoints Weekly! We’ve got a team of reporters on the ground in Chicago this weekend for ASCO, including my fellow Weekly co-author Max Gelman. If you haven’t already, check out Ma…
    Endpoints · 1mo ago↗ source
  • Next FDA user fee deal is under review at the White House
    The White House is examining a deal recently reached by the FDA and the biopharma industry that sets the prescription drug user fees that the sector will pay the agency from 2028 through 2032, sour…
    Endpoints · 1mo ago↗ source
  • Post-Hoc: Lilly gets more secretive and hides Phase 1 pipeline
    Eli Lilly is getting more opaque as it gets bigger. Earlier this year, the drugmaker stopped disclosing its early-stage pipeline work. Its Phase 1 projects vanished from the company’s earnings pr…
    Endpoints · 1mo ago↗ source
  • AstraZeneca seeks path for failed antibody; Imfinzi, Tremfya get label expansions
    🔎 AstraZeneca narrows path for failed antibody: The company announced last summer that its monoclonal antibody anselamimab missed the primary endpoint in a pair of Phase 3 trials for patients with…
    Endpoints · 1mo ago↗ source
  • Replimune will again submit its melanoma drug for approval
    Third time’s the charm? Replimune announced Friday that it will submit its advanced melanoma drug RP1 for FDA review after two prior rejections. It said it has had new discussions with ...
    Endpoints · 1mo ago↗ source
  • Agios ends development of tebapivat in low-risk MDS following subpar results
    Agios Pharmaceuticals has said it will stop developing its rare blood disorder drug for certain patients with myelodysplastic syndromes (MDS) due to disappointing Phase 2b data. The biotech’s pyr…
    Endpoints · 1mo ago↗ source
  • #ASCO26: Bristol Myers details Phase 3 trial win for Pomalyst successor
    Bristol Myers Squibb’s next-gen multiple myeloma drug cut the risk of disease progression or death for certain patients by 52% when added on top of a combination treatment regimen. The New Jersey…
    Endpoints · 1mo ago↗ source
  • David Chang to hand over the reins at Allogene; Ex-Esperion CEO gets started at Phlow
    Longtime Allogene CEO David Chang will be stepping down at the end of June. Chang has served as the company’s CEO for the past eight years and will be succeeded by ...
    Endpoints · 1mo ago↗ source
  • Pfizer strikes Innovent deal worth up to $10.5B for a dozen cancer programs
    On the eve of this year’s ASCO annual meeting, Pfizer said it is teaming up with China’s Innovent Biologics to advance a portfolio of 12 early-stage antibody-drug conjugates and multi-specific anti…
    Endpoints · 1mo ago↗ source
  • Lilly obesity meds Foundayo and Zepbound to gain CVS coverage
    Eli Lilly’s flagship obesity medications will be included in CVS Caremark formularies, likely boosting sales in the most competitive commercial drug market. The company announced Thursday that it…
    Endpoints · 1mo ago↗ source
  • For wearables, it’s a GLP-1 world
    We have two pieces of wearables-related news for you today, and (maybe unsurprisingly) GLP-1s came up in our conversations with both companies. First, Signos raised $20 million for its approach ...
    Endpoints · 1mo ago↗ source
  • ICON audit finds overstated revenue; Secretome and Psilera raise cash
    👀 ICON’s audit probe is complete: The investigation found that ICON’s revenue was overstated by $65.3 million in 2023 (about 0.8% of its total revenue that year) and by $92.7 million in 2024 (1.1%…
    Endpoints · 1mo ago↗ source
  • #ASCO26: After leaving Legend, Frank Fan is ready to showcase his next project
    In 2022, Frank Fan moved more than 800 miles from Nanjing to Shenzhen, China, seeking a fresh start. He had abruptly left Legend Biotech, the CAR-T company he co-founded, just one month after the m…
    Endpoints · 1mo ago↗ source
  • Niowave’s $75M radioisotope facility; CordenPharma to buy AmbioPharm
    Plus, news about Agilent’s earnings report: ☢️ Niowave’s radioisotope factory: The company has broken ground on a $75 million production facility in Lansing, MI, which will be used to manufacture…
    Endpoints · 1mo ago↗ source
  • Charles River CEO says it likely won’t be the last manufacturer to break away from cell and gene therapy
    Three months ago, Charles River Laboratories announced it would shed its manufacturing unit, which has a focus on cell and gene therapies. And, according to its CEO Birgit Girshick, other companies…
    Endpoints · 1mo ago↗ source
  • China gene editing startup YolTech raises $70M to move CRISPR therapies forward
    One of China’s most prolific gene editing companies has raised its biggest round of funding yet, ahead of plans to go public in Hong Kong. While most gene editing companies in the US trimmed their…
    Endpoints · 1mo ago↗ source
  • Oura pushes deeper into healthcare services as part of new ring launch
    Alongside the debut of Oura's smaller Ring 5, the wearables company on Thursday unveiled its plans to help users integrate health records and translate their ring’s findings into medical care. Ou…
    Endpoints · 1mo ago↗ source