<![CDATA[Treatment Sequencing in Metastatic Castration-Resistant Prostate Cancer]]>

Advertisement Opinion|Videos|May 13, 2026 Treatment Sequencing in Metastatic Castration-Resistant Prostate Cancer Author(s)Pedro C. Barata, MD, MSc, FACP , Johann de Bono, MD, PhD Dr. Johann De Bono and Dr. Pedro Barata discuss the evolving role of treatment sequencing and patient selection for radiopharmaceuticals in metastatic castration-resistant prostate cancer (mCRPC). Advertisement Episodes in this seriesEP. 1 Radiopharmaceutical Strategies in Metastatic Castration-Resistant Prostate CancerEP. 2 Combination Radiopharmaceutical Approaches in Metastatic Castration-Resistant Prostate CancerEP. 3 Alpha-Emitting Therapies in Metastatic Castration-Resistant Prostate CancerEP. 4 Patient Selection for Radiopharmaceuticals in Metastatic Castration-Resistant Prostate CancerNow PlayingEP. 5 Treatment Sequencing in Metastatic Castration-Resistant Prostate CancerEP. 6 Combination and Sequencing Strategies in Metastatic Castration-Resistant Prostate CancerEP. 7 Safety and Toxicity Management in Metastatic Castration-Resistant Prostate CancerEP. 8 Future Radiopharmaceutical Strategies in Metastatic Castration-Resistant Prostate CancerEP. 9 Personalized Treatment Decision-Making in Metastatic Castration-Resistant Prostate CancerEP. 10 Future Directions in Metastatic Castration-Resistant Prostate Cancer Dr. Johann De Bono and Dr. Pedro Barata discuss the evolving role of treatment sequencing and patient selection for radiopharmaceuticals in metastatic castration-resistant prostate cancer (mCRPC). Dr. Barata highlights the growing complexity of integrating radiopharmaceuticals alongside chemotherapy, androgen receptor pathway inhibitors, and PSMA-targeted therapies as new clinical data emerge. The faculty review studies comparing lutetium-based PSMA therapies with taxane chemotherapy and discuss how differences in imaging requirements, tumor burden, PSMA expression, and disease heterogeneity may influence treatment selection in both clinical trials and real-world practice. Dr. Barata also explores how factors such as visceral disease, genomic alterations, and aggressive tumor biology may impact the likelihood of response to PSMA-targeted therapies and guide clinicians toward alternative approaches such as chemotherapy. In addition, the conversation addresses sequencing considerations between radium Ra 223 dichloride and PSMA-targeted therapies, including emerging real-world evidence supporting the feasibility of sequential radiopharmaceutical treatment strategies in mCRPC. NewsletterStay up to date on the most recent and practice-changing oncology dataSubscribe Now! Advertisement Related ContentAdvertisementFuture Directions in Metastatic Castration-Resistant Prostate CancerByPedro C. Barata, MD, MSc, FACP ,Johann de Bono, MD, PhDMay 13th 2026Personalized Treatment Decision-Making in Metastatic Castration-Resistant Prostate CancerByPedro C. Barata, MD, MSc, FACP ,Johann de Bono, MD, PhDMay 13th 2026Future Radiopharmaceutical Strategies in Metastatic Castration-Resistant Prostate CancerByPedro C. Barata, MD, MSc, FACP ,Johann de Bono, MD, PhDMay 13th 2026Safety and Toxicity Management in Metastatic Castration-Resistant Prostate CancerByPedro C. Barata, MD, MSc, FACP ,Johann de Bono, MD, PhDMay 13th 2026Combination and Sequencing Strategies in Metastatic Castration-Resistant Prostate CancerByPedro C. 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