<![CDATA[Radiopharmaceutical Strategies in Metastatic Castration-Resistant Prostate Cancer]]>

Advertisement Opinion|Videos|May 13, 2026 Radiopharmaceutical Strategies in Metastatic Castration-Resistant Prostate Cancer Author(s)Pedro C. Barata, MD, MSc, FACP , Johann de Bono, MD, PhD Dr. Pedro Barata and Dr. Johann De Bono open the discussion by reviewing the evolving role of radiopharmaceuticals in metastatic castration-resistant prostate cancer (mCRPC) and outlining how these therapies are being integrated into the broader treatment landscape. Advertisement Episodes in this seriesNow PlayingEP. 1 Radiopharmaceutical Strategies in Metastatic Castration-Resistant Prostate CancerEP. 2 Combination Radiopharmaceutical Approaches in Metastatic Castration-Resistant Prostate CancerEP. 3 Alpha-Emitting Therapies in Metastatic Castration-Resistant Prostate CancerEP. 4 Patient Selection for Radiopharmaceuticals in Metastatic Castration-Resistant Prostate CancerEP. 5 Treatment Sequencing in Metastatic Castration-Resistant Prostate CancerEP. 6 Combination and Sequencing Strategies in Metastatic Castration-Resistant Prostate CancerEP. 7 Safety and Toxicity Management in Metastatic Castration-Resistant Prostate CancerEP. 8 Future Radiopharmaceutical Strategies in Metastatic Castration-Resistant Prostate CancerEP. 9 Personalized Treatment Decision-Making in Metastatic Castration-Resistant Prostate CancerEP. 10 Future Directions in Metastatic Castration-Resistant Prostate Cancer Dr. Pedro Barata and Dr. Johann De Bono open the discussion by reviewing the evolving role of radiopharmaceuticals in metastatic castration-resistant prostate cancer (mCRPC) and outlining how these therapies are being integrated into the broader treatment landscape. Dr. De Bono discusses the development of radiopharmaceutical approaches in mCRPC, beginning with radium Ra 223 dichloride as an established bone-targeting alpha-emitting therapy associated with improved survival outcomes and the importance of bone-protective agents in mitigating fracture risk. The conversation then transitions to PSMA-targeted radioligand therapies and the distinctions between alpha- and beta-emitting agents, including differences in penetration, energy delivery, efficacy, and toxicity profiles. Dr. De Bono also highlights emerging next-generation compounds and explains how these therapies induce tumor cell death through DNA damage. Together, the faculty provide a practical and evidence-based overview of the rapidly evolving radiopharmaceutical landscape in mCRPC. NewsletterStay up to date on the most recent and practice-changing oncology dataSubscribe Now! Advertisement Related ContentAdvertisementFuture Directions in Metastatic Castration-Resistant Prostate CancerByPedro C. Barata, MD, MSc, FACP ,Johann de Bono, MD, PhDMay 13th 2026Personalized Treatment Decision-Making in Metastatic Castration-Resistant Prostate CancerByPedro C. Barata, MD, MSc, FACP ,Johann de Bono, MD, PhDMay 13th 2026Future Radiopharmaceutical Strategies in Metastatic Castration-Resistant Prostate CancerByPedro C. Barata, MD, MSc, FACP ,Johann de Bono, MD, PhDMay 13th 2026Safety and Toxicity Management in Metastatic Castration-Resistant Prostate CancerByPedro C. Barata, MD, MSc, FACP ,Johann de Bono, MD, PhDMay 13th 2026Combination and Sequencing Strategies in Metastatic Castration-Resistant Prostate CancerByPedro C. Barata, MD, MSc, FACP ,Johann de Bono, MD, PhDMay 13th 2026 Latest CMEMultimediaCommunity Practice Connections™: Empowering Interventional Radiologists in the Emerging Era of Oncolytic Immunotherapies for MelanomaYana G. Najjar, MD; Douglas B. 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