<![CDATA[Combination Radiopharmaceutical Approaches in Metastatic Castration-Resistant Prostate Cancer]]>

Advertisement Opinion|Videos|May 13, 2026 Combination Radiopharmaceutical Approaches in Metastatic Castration-Resistant Prostate Cancer Author(s)Pedro C. Barata, MD, MSc, FACP , Johann de Bono, MD, PhD Dr. Pedro Barata and Dr. Johann De Bono discuss emerging combination strategies involving radiopharmaceuticals in metastatic castration-resistant prostate cancer (mCRPC), with a focus on the scientific rationale behind combining these agents with other systemic therapies. Advertisement Episodes in this seriesEP. 1 Radiopharmaceutical Strategies in Metastatic Castration-Resistant Prostate CancerNow PlayingEP. 2 Combination Radiopharmaceutical Approaches in Metastatic Castration-Resistant Prostate CancerEP. 3 Alpha-Emitting Therapies in Metastatic Castration-Resistant Prostate CancerEP. 4 Patient Selection for Radiopharmaceuticals in Metastatic Castration-Resistant Prostate CancerEP. 5 Treatment Sequencing in Metastatic Castration-Resistant Prostate CancerEP. 6 Combination and Sequencing Strategies in Metastatic Castration-Resistant Prostate CancerEP. 7 Safety and Toxicity Management in Metastatic Castration-Resistant Prostate CancerEP. 8 Future Radiopharmaceutical Strategies in Metastatic Castration-Resistant Prostate CancerEP. 9 Personalized Treatment Decision-Making in Metastatic Castration-Resistant Prostate CancerEP. 10 Future Directions in Metastatic Castration-Resistant Prostate Cancer Dr. Pedro Barata and Dr. Johann De Bono discuss emerging combination strategies involving radiopharmaceuticals in metastatic castration-resistant prostate cancer (mCRPC), with a focus on the scientific rationale behind combining these agents with other systemic therapies. Dr. De Bono reviews ongoing investigations evaluating radiopharmaceuticals alongside androgen receptor pathway inhibitors, PARP inhibitors, chemotherapy, and immunotherapy, highlighting how these approaches may enhance PSMA expression, increase DNA damage, and potentially improve tumor targeting. The discussion also explores evolving concepts surrounding alpha-emitting therapies, including radium Ra 223 dichloride and actinium-based approaches, as well as the growing interest in tandem and PSMA-targeted strategies. Importantly, the faculty emphasize the need to balance efficacy with tolerability, particularly regarding hematologic toxicities, chronic anemia, and long-term bone marrow effects associated with combination approaches. Together, the conversation provides insight into the future direction of radiopharmaceutical development and combination strategies in mCRPC. NewsletterStay up to date on the most recent and practice-changing oncology dataSubscribe Now! Advertisement Related ContentAdvertisementFuture Directions in Metastatic Castration-Resistant Prostate CancerByPedro C. Barata, MD, MSc, FACP ,Johann de Bono, MD, PhDMay 13th 2026Personalized Treatment Decision-Making in Metastatic Castration-Resistant Prostate CancerByPedro C. Barata, MD, MSc, FACP ,Johann de Bono, MD, PhDMay 13th 2026Future Radiopharmaceutical Strategies in Metastatic Castration-Resistant Prostate CancerByPedro C. Barata, MD, MSc, FACP ,Johann de Bono, MD, PhDMay 13th 2026Safety and Toxicity Management in Metastatic Castration-Resistant Prostate CancerByPedro C. Barata, MD, MSc, FACP ,Johann de Bono, MD, PhDMay 13th 2026Combination and Sequencing Strategies in Metastatic Castration-Resistant Prostate CancerByPedro C. Barata, MD, MSc, FACP ,Johann de Bono, MD, PhDMay 13th 2026 Latest CMEMultimediaCommunity Practice Connections™: Empowering Interventional Radiologists in the Emerging Era of Oncolytic Immunotherapies for MelanomaYana G. Najjar, MD; Douglas B. 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