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oxycodone ER

Marketedupdated 2mo ago

by $COLL COLLEGIUM PHARMACEUTICAL, INC

Approved

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Small molecule drug with a maximum clinical stage of Approval (across all indications), with 3 approved and 30 investigational indications.

all catalysts(13)

approval · 13

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brand

Xtampza ER

generic

oxycodone

MOA

12.1 Mechanism of Action Oxycodone is a full opioid agonist and is relatively selective for the mu receptor, although it can bind to other opioid receptors at higher doses. The principal therapeutic action of oxycodone is analgesia. Like all full opioid agonists, there is no ceiling effect to analgesia for oxycodone. Clinically, dosage is titrated to provide adequate analgesia and may be limited by adverse reactions, including respiratory and CNS depression. The precise mechanism of the analgesic action is unknown. However, specific CNS opioid receptors for endogenous compounds with opioid-like activity have been identified throughout the brain and spinal cord and are thought to play a role in the analgesic effects of this drug. In addition, when oxycodone binds to mu-opioid receptors, it results in positive subjective effects, such as drug liking, euphoria, and high.

indication

Pain

phase

marketed

oxycodone ER

all catalysts(13)

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Trials studying oxycodone ER