drug · small molecule

HYDROCODONE BITARTRATE AND ACETAMINOPHEN

updated 2mo ago

by $IGC IGC Pharma, Inc.🔗 ChEMBL

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Small molecule drug with a maximum clinical stage of Approval (across all indications), with 18 approved and 81 investigational indications.

targets

CyclooxygenaseFatty-acid amide hydrolase 1Transient receptor potential cation channel subfamily V member 1

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brand

HYDROCODONE BITARTRATE AND ACETAMINOPHEN

trade names

Abdine, Acephen, Acetaminophen, Acetaminophen component of allay, Acetaminophen component of anexsia, Acetaminophen component of anoquan

generic

ACETAMINOPHEN

MOA

Mechanism of Action Hydrocodone is a full opioid agonist with relative selectivity for the mu-opioid (µ) receptor, although it can interact with other opioid receptors at higher doses. The principal therapeutic action of hydrocodone is analgesia. Like all full opioid agonists, there is no ceiling effect for analgesia with hydrocodone. Clinically, dosage is titrated to provide adequate analgesia and may be limited by adverse reactions, including respiratory and CNS depression. The precise mechanism of the analgesic action is unknown. However, specific CNS opioid receptors for endogenous compounds with opioid-like activity have been identified throughout the brain and spinal cord and are thought to play a role in the analgesic effects of this drug. The precise mechanism of the analgesic properties of acetaminophen is not established but is thought to involve central actions.

indication

INDICATIONS AND USAGE Hydrocodone Bitartrate and Acetaminophen Tablets, USP are indicated for the management of pain severe enough to require an opioid analgesic and for which alternative treatments are inadequate. Limitations of Use Because of the risks of addiction, abuse, and misuse with opioids, which can occur at any dosage or duration [see WARNINGS ] , reserve hydrocodone bitartrate and acetaminophen tablets for use in patients for whom alternative treatment options (e.g., non-opioid analgesics or opioid combination products): Have not been tolerated or are not expected to be tolerated, Have not provided adequate analgesia or are not expected to provide adequate analgesia Hydrocodone bitartrate and acetaminophen tablets should not be used for an extended period of time unless the pain remains severe enough to require an opioid analgesic and for which alternative treatment options continue to be inadequate.

HYDROCODONE BITARTRATE AND ACETAMINOPHEN

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Trials studying HYDROCODONE BITARTRATE AND ACETAMINOPHEN