drug · small molecule

XTAMPZA ER

updated 3mo ago

/ OK-see-KOH-dohn /

by $COLL COLLEGIUM PHARMACEUTICAL, INC🔗 ChEMBL

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Small molecule drug with a maximum clinical stage of Approval (across all indications), with 3 approved and 30 investigational indications.

targets

Mu-type opioid receptor

all catalysts(0)

nothing on the calendar yet

Trials studying XTAMPZA ER

—Anesthetics and Analgesics in Childrenrecruitingn=500
—Pharmacokinetics and Safety of Commonly Used Drugs in Lactating Women and Breastfed Infantsrecruitingn=1,600
N/AIntercostal Nerve Cryoablation Versus Epidural Analgesia for Nuss Repair of Pectus Excavatumcompletedn=50
phase3A Study of Cebranopadol for the Treatment of Acute Pain After Bunionectomycompletedn=240
phase1A Study to Investigate the Pharmacodynamic Effect of Single Doses of MT-8554 in Healthy Subjectscompletedn=20
phase1Buprenorphine-Fentanyl Interaction Studycompletedn=22
—Impact of Opioid Avoidance Protocol for ACL Reconstructioncompletedn=32
phase3Fixed-dose Combination of Oxycodone [OXIcodona] + IbuproFEN in Pain Relief After Third Molar Extractioncompletedn=288

more trials →

News(2)

STAT+: Latigo reports mid-stage success for would-be rival to Vertex’s pain drug Journavx
Latigo Biotherapeutics published positive data for an acute-pain drug meant to rival a Vertex medicine already on the market
stat · 16d ago
Super-potent synthetic opioids called nitazenes are spreading across the U.S.
Overdose deaths confirmed to involve nitazenes have risen sharply in the U.S., from 27 in 2020 to 409 in 2024, according to the CDC
stat · 1mo ago

brand

XTAMPZA ER

trade names

Proladone, Xtampza er

generic

OXYCODONE

MOA

12.1 Mechanism of Action Oxycodone is a full opioid agonist and is relatively selective for the mu receptor, although it can bind to other opioid receptors at higher doses. The principal therapeutic action of oxycodone is analgesia. Like all full opioid agonists, there is no ceiling effect to analgesia for oxycodone. Clinically, dosage is titrated to provide adequate analgesia and may be limited by adverse reactions, including respiratory and CNS depression. The precise mechanism of the analgesic action is unknown. However, specific CNS opioid receptors for endogenous compounds with opioid-like activity have been identified throughout the brain and spinal cord and are thought to play a role in the analgesic effects of this drug. In addition, when oxycodone binds to mu-opioid receptors, it results in positive subjective effects, such as drug liking, euphoria, and high.

indication

1 INDICATIONS AND USAGE XTAMPZA ER is indicated for the management of severe and persistent pain that requires an opioid analgesic and that cannot be adequately treated with alternative options, including immediate-release opioids. XTAMPZA ER is an opioid agonist indicated for the management of severe and persistent pain that requires an opioid analgesic and that cannot be adequately treated with alternative options, including immediate-release opioids. ( 1 ) Limitations of Use Because of the risks of addiction, abuse, misuse, overdose, and death,which can occur at any dosage or duration and persist over the course of therapy, reserve opioid analgesics, including XTAMPZA ER, for use in patients for whom alternative treatment optionsare ineffective, not tolerated, or would be otherwise inadequate to provide sufficient management of pain. ( 1 , 5.1 ) XTAMPZA ER is not indicated as an as-needed (prn) analgesic. ( 1 ) Limitations of Use Because of the risks of addiction, abuse, misuse, overdose, and death, which can occur at any dosage or duration and persist over the course of therapy [see Warnings and Precautions (5.1) ], reserve opioid analgesics, including XTAMPZA ER, for use in patients for whom alternative treatment options are ineffective, not tolerated, or would be otherwise inadequate to provide sufficient management of pain. XTAMPZA ER is not indicated as an as-needed (prn) analgesic.

Data sources

ClinicalTrials.gov · OpenTargets

last refreshed 15m ago

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drug · small molecule

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XTAMPZA ER

updated 3mo ago

/ OK-see-KOH-dohn /

by $COLL COLLEGIUM PHARMACEUTICAL, INC🔗 ChEMBL

community read0 votes

🐶 often sniffed alongside

top 8

Small molecule drug with a maximum clinical stage of Approval (across all indications), with 3 approved and 30 investigational indications.

targets

Mu-type opioid receptor

all catalysts(0)

nothing on the calendar yet

Trials studying XTAMPZA ER

—Anesthetics and Analgesics in Childrenrecruitingn=500
—Pharmacokinetics and Safety of Commonly Used Drugs in Lactating Women and Breastfed Infantsrecruitingn=1,600
N/AIntercostal Nerve Cryoablation Versus Epidural Analgesia for Nuss Repair of Pectus Excavatumcompletedn=50
phase3A Study of Cebranopadol for the Treatment of Acute Pain After Bunionectomycompletedn=240
phase1A Study to Investigate the Pharmacodynamic Effect of Single Doses of MT-8554 in Healthy Subjectscompletedn=20
phase1Buprenorphine-Fentanyl Interaction Studycompletedn=22
—Impact of Opioid Avoidance Protocol for ACL Reconstructioncompletedn=32
phase3Fixed-dose Combination of Oxycodone [OXIcodona] + IbuproFEN in Pain Relief After Third Molar Extractioncompletedn=288

more trials →

News(2)

STAT+: Latigo reports mid-stage success for would-be rival to Vertex’s pain drug Journavx
Latigo Biotherapeutics published positive data for an acute-pain drug meant to rival a Vertex medicine already on the market
stat · 16d ago
Super-potent synthetic opioids called nitazenes are spreading across the U.S.
Overdose deaths confirmed to involve nitazenes have risen sharply in the U.S., from 27 in 2020 to 409 in 2024, according to the CDC
stat · 1mo ago

brand

XTAMPZA ER

trade names

Proladone, Xtampza er

generic

OXYCODONE

MOA

indication

Data sources

ClinicalTrials.gov · OpenTargets

last refreshed 15m ago

Found something off?

comments(0)

5-min edit window · permanent after that

no comments yet — first sniff?

XTAMPZA ER

🐶 often sniffed alongside

targets

all catalysts(0)

Trials studying XTAMPZA ER

News(2)

Report a data issue

comments(0)

XTAMPZA ER

🐶 often sniffed alongside

targets

all catalysts(0)

Trials studying XTAMPZA ER

News(2)

Report a data issue

comments(0)