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  • #ADA26: Novo Nordisk targets 2030 launch for triple-G obesity shot
    The molecules known as triple-Gs — agonists of GLP-1, GIP and glucagon — are drawing attention as data build suggesting they could be the most effective class of obesity drugs. Eli Lilly is leading…
    Endpoints · 2mo ago↗ source
  • STAT+: J&J spends $1 billion to enter KRAS race for cancer treatments
    Johnson & Johnson said it will purchase the startup Firefly Bio for $1 billion in an effort to expand its work in the suddenly buzzy field of KRAS inhibitors.
    STAT · 2mo ago↗ source
  • Major readouts from the annual diabetes conference
    Why "Schedule F" matters, the Ebola outbreak response, and more health news from Morning Rounds
    STAT · 2mo ago↗ source
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  • STAT+: Combination of pancreatic cancer drugs from Tango, Revolution leads to high response rate
    A combination of pancreatic cancer drugs from Tango Therapeutics and Revolution Medicines led to a strong response rate in an early-stage trial.
    STAT · 2mo ago↗ source
  • Incyte to buy bleeding disorder biotech Vega Therapeutics in $1.25B upfront deal
    Incyte plans to spend $1.25 billion upfront to buy Star Therapeutics' subsidiary Vega Therapeutics and its Phase 3 bleeding disorder candidate, the companies said Monday. The deal package also incl…
    Endpoints · 2mo ago↗ source
  • Takeda says it expects to take $2.5B hit after Amitiza antitrust verdict, with plans to appeal
    Takeda has updated its financial results to reflect costs it could incur after losing an antitrust lawsuit concerning its laxative drug Amitiza. In May, the US District Court in Massachusetts ruled…
    Endpoints · 2mo ago↗ source
  • Nurix to work with Roche on BTK degrader in pact worth up to $2.3B
    Roche is set to pay Nurix Therapeutics $700 million upfront to collaborate on a BTK degrader for B cell malignancies, with broader plans in immunology and neurology. The deal could be ...
    Endpoints · 2mo ago↗ source
  • When it’s time to save a limb, novel clinic meets unhoused people where they are
    Unmet vascular needs can lead to limb loss among unhoused patients. An unusual Massachusetts General Hospital program meets patients where they are.
    STAT · 2mo ago↗ source
  • Opinion: American horses are obese, too
    “American horses are getting sick in ways that look remarkably familiar,” writes Joshua Moen.
    STAT · 2mo ago↗ source
  • Opinion: $2 million gene therapy cures require a financing model
    “We do not lack cures. We lack the infrastructure to pay for and deliver them,” writes William Padula.
    STAT · 2mo ago↗ source
  • STAT+: Competition for obesity drugs, clinical blind spots, and more news from ADA
    You're reading the web edition of STAT's ADA in 30 Seconds, from the American Diabetes Association's annual conference.
    STAT · 2mo ago↗ source
  • #ADA26: 19% of Phase 3 patients quit Boehringer obesity shot over side effects
    Boehringer Ingelheim’s obesity asset survodutide, which it licensed from Zealand Pharma, has shown high rates of discontinuations in its Phase 3 obesity study. In April, data from the SYNCHRONIZE-1…
    Endpoints · 2mo ago↗ source
  • STAT+: New data may cast doubt on competitiveness of Boehringer’s obesity drug
    Boehringer Ingelheim’s obesity drug showed promise in cutting liver fat, but it was less impressive at overall weight loss, new data shows.
    STAT · 2mo ago↗ source
  • STAT+: Triple hormone receptors, a monthly obesity drug, and a bittersweet ending
    You're reading the web edition of STAT's ADA in 30 Seconds, from the American Diabetes Association's annual conference in New Orleans.
    STAT · 2mo ago↗ source
  • STAT+: Lilly shares safety, tolerability data on its next-gen obesity drug
    Eli Lilly presented new safety and tolerability data on retatrutide at the annual meeting of the American Diabetes Association on Saturday.
    STAT · 2mo ago↗ source
  • #ADA26: Pfizer's monthly shot shows effect on obesity, diabetes
    The long-acting GLP-1 shot that was the centerpiece of Pfizer’s acquisition of Metsera last year looks effective in patients with both obesity and diabetes, according to data presented Saturday. Be…
    Endpoints · 2mo ago↗ source
  • STAT+: Detailed data show Pfizer’s monthly obesity drug continues to show potential
    Detailed data from a midstage study offered further evidence that the obesity drug Pfizer acquired from the biotech Metsera could be dosed monthly.
    STAT · 2mo ago↗ source
  • #ADA26: Roche to start Phase 2 petrelintide, enicepatide combo trial this year
    Roche says it has one obesity drug with a potential best-in-class safety profile, and another with a similar shot at leading in efficacy. Combining them could produce a highly successful product if…
    Endpoints · 2mo ago↗ source
  • Lawmakers propose China restrictions; #ASCO26 recap; and more
    Welcome back to Endpoints Weekly! We had a small team in Chicago last weekend at this year’s ASCO conference. You’ll find a recap of their coverage below, including more details on Revolution Medic…
    Endpoints · 2mo ago↗ source
  • Opinion: How the Amish think about vaccines, health care costs, and much more
    There may be nearly 2 million Amish Americans by 2075. That has large public health implications.
    STAT · 2mo ago↗ source
  • Opinion: I led the U.S. CDC response to the 2014 Ebola epidemic. The new outbreak needs massive, immediate, meticulous action
    “Ebola is an unforgiving enemy,” writes Tom Frieden, who led the U.S. CDC response to the 2014-2016 Ebola outbreak.
    STAT · 2mo ago↗ source
  • #ADA26: Roche's incretin shot works in mid-stage trial in type 1 diabetes
    A daily incretin shot being developed by Roche has shown promise in type 1 diabetes — the form that is not generally believed to be directly treatable by GLP-1-based drugs. According to Phase 2 dat…
    Endpoints · 2mo ago↗ source
  • CDC: Ebola outbreak in Central Africa could reach 20,000 cases without strong countermeasures
    The Ebola outbreak in Central Africa could grow to 20,000 cases or more, depending on how quickly infected people are isolated to slow the spread, according to a new U.S. analysis.
    STAT · 2mo ago↗ source
  • STAT+: Newer GLP-1s, pushback on research cuts, and a protest
    You're reading the web edition of STAT's ADA in 30 Seconds, from the American Diabetes Association's annual conference in New Orleans.
    STAT · 2mo ago↗ source
  • STAT+: What stripping civil service protections for thousands of federal workers will mean for HHS
    Thousands of HHS staff who shape policy have had their employment status changed to a designation that makes it easier for them to be fired.
    STAT · 2mo ago↗ source