Study finds childhood platinum chemotherapy ages liver cells, may increase future cancer risk

A new study published in Science examined children who received platinum‑based chemotherapy, such as cisplatin or carboplatin, followed by surgery for hepatoblastoma. Researchers collected samples from both healthy and tumor‑affected liver tissue to assess long‑term effects.

The analysis showed that the chemotherapy induced mutations in normal liver cells that made them resemble adult cells, effectively accelerating cellular aging. These changes were linked to an increased likelihood of developing new tumors later in life.

The authors suggest that survivors of childhood platinum therapy may need lifelong monitoring for liver health and potential cancers, highlighting a need to balance treatment benefits with long‑term safety considerations.