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Fierce Biotech·Dec 22·1 min read
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Biotech fundraising tracker reports $70M Series C for Ratio Therapeutics and $130M Series B for Crystalys Therapeutics

Dec 22, 2025·read at Fierce Biotech ↗DealNeutral

The Fierce Biotech Fundraising Tracker continues to log only large venture capital rounds, focusing on deals of $50 million or more.

Ratio Therapeutics secured a $70 million Series C, backed by investors including Duquesne Family Office, Bristol Myers Squibb, Catalio Capital Management, Eli Lilly and Company, and Wasatch Group. The company plans to move its lead candidate, RTX-2358, into a combined phase 1/2 study for advanced sarcomas and to expand its oncology pipeline and manufacturing capacity.

Crystalys Therapeutics raised $130 million in a Series B round with participation from a broad group of investors such as Frazier Life Sciences, Wellington Management, Novo Holdings, SR One, and several other venture funds. The funding will support the company’s ongoing development programs, though specific uses were not detailed in the announcement.

source

This writeup was produced by pharmadog from original reporting by Fierce Biotech.

Original headline: “Fierce Biotech Fundraising Tracker '26: Sling reels in $123M; Circle gathers $92.5M”

read at Fierce Biotech ↗
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companies & drugs in this story

companies
LILLY9Sanofi9ELI LILLY CO8LEADING8Ultragenyx Pharmaceutical Inc.7PFIZER6NOVO5ABBVIE4Eli Lilly and Co4LifeArc4NOVARTIS4BRISTOL3BRISTOL MYERS SQUIBB3BRISTOL MYERS SQUIBB CO3JOHNSON & JOHNSON3Crystalys Therapeutics Inc2Moderna, Inc.2Monte Rosa Therapeutics, Inc.2NEXUS2Rakuten Medical Inc2AMGENASTELLASASTRAZENECABeOne Medicines Ltd.Beeline Medicines CorpDana-Farber Cancer Institute IncDenali Therapeutics Inc.Disc Medicine, Inc.Drug Farm IncGENENTECHOTSUKAPATHR1 Therapeutics IncRNA Therapeutics IncROCHESERVIERSPRINGWORKSSage Therapeutics IncSpringWorks Therapeutics Inc
drugs
Lead Candidate11Obesity5Rare Disease4Undisclosed3Immunology2KRSA-0282Lead Program2deupirfenidone2dotinurad2(brimonidine tartrate + carbachol)Bio TCancer ProgramDF-003DT-101ER-100KEYTRUDAPIRFENIDONERTX-015Small MoleculesTEPEZZATestimType 2 DiabetesVABYSMOViral DiseasesVogelxocetuximabdextromethorphanfaricimabironpembrolizumabteprotumumabtestosteronezolucatetide
topics
Oncology28Monoclonal Antibody16Immunology15Small Molecule10Ophthalmology9Pulmonology9Hepatology8Rare Disease7Bispecific Antibody6Hematology6Obesity6Atopic Dermatitis5Cardiology5GLP-1 receptor5Nephrology5siRNA5Antibody-Drug Conjugate (ADC)4Molecular Glue4Pulmonary Fibrosis4AMD3CAR-T3Cell Therapy3EGFR3NSCLC3Type 2 Diabetes3AML2Asthma2CD192COPD2Endocrinology & Metabolism2IBD (Crohn's + UC)2Major Depression2Medical Device Company2Neurology2Peptide Therapeutic2Prostate Cancer2Psoriasis2Vaccines2mRNA Therapeutic2ALSAntisense Oligonucleotide (ASO)BCMABig PharmaBreast CancerColorectal CancerDiabetic Macular EdemaDuchenne Muscular DystrophyEpilepsyGene Therapy (AAV)IL-17Infectious DiseaseJAKOrthopedicsPI3KPlatform CompanySchizophreniaType 1 DiabetesVaccine

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