Long-term brain organoids survive over five years and develop molecular features of human brains

Researchers at Harvard have kept brain organoids alive for more than five years, observing continued growth and maturation that mirrors human brain development.

The long-term cultures displayed molecular and genetic signatures similar to those found in actual human brains, suggesting they could serve as valuable models for studying early stages of neurological disorders.

The discovery, reported in a STAT+ exclusive article, highlights the potential of organoid technology to improve disease modeling and drug discovery, though further work is needed to translate these findings into clinical applications.