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  1. pharmadog
  2. ›drugs
  3. ›YUSIMRY
drug · antibody
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YUSIMRY

Marketedupdated 5mo ago
by $COGT Cogent Biosciences, Inc.🔗 ChEMBL
Approved
community read0 votes

🐶 often sniffed alongside

top 8
  • tagApproval182 co-mentions · 86 sources
  • drugHUMIRA172 co-mentions · 86 sources
  • drugadalimumab152 co-mentions · 86 sources
  • drugAMJEVITA81 co-mentions · 81 sources
  • drugABRILADA81 co-mentions · 81 sources
  • company$ABBVAbbVie Inc.61 co-mentions · 61 sources
  • drugCYLTEZO24 co-mentions · 12 sources
  • drugIDACIO16 co-mentions · 8 sources

Antibody drug with a maximum clinical stage of Approval (across all indications), with 14 approved and 20 investigational indications.

targets

Tumor necrosis factor

all catalysts(5)

approval · 5
Dec 17, 2021
approval
$COGT31.02-1.80%
5y ago
YUSIMRY (ADALIMUMAB-AQVH) — FDA approval
YUSIMRY
→
Feb 27, 2023
approval
$COGT31.02-1.80%
4y ago
YUSIMRY (ADALIMUMAB-AQVH) — FDA approval
YUSIMRY
→
Mar 31, 2023
approval
$COGT31.02-1.80%
4y ago
YUSIMRY (ADALIMUMAB-AQVH) — FDA approval
YUSIMRY
→
Sep 13, 2023
approval
$COGT31.02-1.80%
3y ago
YUSIMRY (ADALIMUMAB-AQVH) — FDA approval
YUSIMRY
→
Nov 10, 2025
approval
$COGT31.02-1.80%
11mo ago
YUSIMRY (ADALIMUMAB-AQVH) — FDA approval
YUSIMRY
→

News(9)

  • BMO most bullish on Merck's, bearish on BMS’ plans to contend with patent cliffs
    BMO Capital Markets is more impressed by Merck’s plans to replace lost Keytruda revenue than on Bristol Myers Squibb’s efforts to fill the expected void that will come from loss of exclusivity for…
    biospace · 1d ago
  • Merck’s antibody impresses with ‘highly competitive’ data in chronic skin disease
    Merck has revealed detailed data for tulisokibart from a mid-stage trial in hidradenitis suppurativa that analysts say could help carve out a place in a crowded market that already includes AbbVie’…
    biospace · 2d ago
  • 6 immunology targets to sustain a mammoth I&I market
    Johnson & Johnson, Pfizer, Argenx and more are unlocking new immunology targets and looking to improve on existing ones in an attempt to catch some of the magic brought about by AbbVie’s Humira and…
    biospace · 6d ago
  • Drugmakers cherry pick launch regions as MFN creates 'policy environment like an earthquake'
    With multiple drug pricing initiatives like Most Favored Nation now in force, drugmakers have to reinvent their commercial strategies to stay ahead of the fast-moving policy environment, according…
    biospace · 23d ago
  • MoonLake’s nanobody boosts all clinical endpoints in phase 3 psoriatic arthritis trial
    MoonLake Immunotherapeutics announced positive phase 3 data for patients with psoriatic arthritis treated with its lead nanobody candidate, sonelokimab.
    fiercebiotech · 1mo ago
  • AbbVie shares pressured as Q2 I&I beat falls below investor expectations
    AbbVie investors’ sky-high expectations led to a 4% share decline on Friday as the company reported more modest consensus beats than expected.
    biospace · 2mo ago
  • cAMPfield lands $180M to build gut disease drug
    The biotech is advancing an anti-inflammatory drug that originated with vTv for inflammatory bowel diseases, leaning on a better side effect profile.
    biopharma_dive · 3mo ago
  • Biogen adds more immune drugs in $1B buyout of secretive startup RayThera
    The companies didn’t specify the drugs Biogen is acquiring in the deal, though patents RayThera secured provide important clues.
    biopharma_dive · 3mo ago
  • Opinion: The podcast telling the stories behind Ambien, Ozempic, EpiPens, and other game-changing drugs
    “We're basically not using our body as directed,” says "Drug Story" host Thomas Goetz.
    stat · 5mo ago
brand
YUSIMRY
trade names
Amgevita, Amsparity, Cyltezo, Halimatoz, Hefiya, Hulio
generic
ADALIMUMAB-AQVH
MOA
12.1 Mechanism of Action Adalimumab products bind specifically to TNF-alpha and block its interaction with the p55 and p75 cell surface TNF receptors. Adalimumab products also lyse surface TNF expressing cells in vitro in the presence of complement. Adalimumab products do not bind or inactivate lymphotoxin (TNF-beta). TNF is a naturally occurring cytokine that is involved in normal inflammatory and immune responses. Elevated concentrations of TNF are found in the synovial fluid of patients with RA, JIA, PsA, and AS and play an important role in both the pathologic inflammation and the joint destruction that are hallmarks of these diseases. Increased concentrations of TNF are also found in psoriasis plaques. In Ps, treatment with YUSIMRY may reduce the epidermal thickness and infiltration of inflammatory cells. The relationship between these pharmacodynamic activities and the mechanism(s) by which adalimumab products exert their clinical effects is unknown. Adalimumab products also modulate biological responses that are induced or regulated by TNF, including changes in the concentrations of adhesion molecules responsible for leukocyte migration (ELAM-1, VCAM-1, and ICAM-1 with an IC 50 of 1-2 X 10 -10 M).
phase
marketed
Data sources
openFDA · ClinicalTrials.gov · OpenTargets
last refreshed 3h ago
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