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  1. pharmadog
  2. ›drugs
  3. ›AMJEVITA
drug · antibody
save

AMJEVITA

Marketedupdated 3mo ago
by $AMGN AMGEN INC🔗 ChEMBL
Approved
community read0 votes

🐶 often sniffed alongside

top 8
  • tagApproval214 co-mentions · 94 sources
  • drugHUMIRA188 co-mentions · 94 sources
  • drugadalimumab168 co-mentions · 94 sources
  • drugYUSIMRY81 co-mentions · 81 sources
  • drugABRILADA81 co-mentions · 81 sources
  • company$ABBVAbbVie Inc.61 co-mentions · 61 sources
  • company$AMGNAMGEN INC26 co-mentions · 13 sources
  • drugCYLTEZO24 co-mentions · 12 sources

Antibody drug with a maximum clinical stage of Approval (across all indications), with 14 approved and 20 investigational indications.

targets

Tumor necrosis factor

all catalysts(13)

approval · 13
Sep 23, 2016
approval
$AMGN414.30-0.70%
10y ago
AMJEVITA (ADALIMUMAB-ATTO) — FDA approval
AMJEVITA
→
Mar 15, 2018
approval
$AMGN414.30-0.70%
8y ago
AMJEVITA (ADALIMUMAB-ATTO) — FDA approval
AMJEVITA
→
Jun 13, 2019
approval
$AMGN414.30-0.70%
7y ago
AMJEVITA (ADALIMUMAB-ATTO) — FDA approval
AMJEVITA
→
Jul 28, 2022
approval
$AMGN414.30-0.70%
4y ago
AMJEVITA (ADALIMUMAB-ATTO) — FDA approval
AMJEVITA
→
Mar 22, 2023
approval
$AMGN414.30-0.70%
3y ago
AMJEVITA (ADALIMUMAB-ATTO) — FDA approval
AMJEVITA
→
Apr 6, 2023
approval
$AMGN414.30-0.70%
3y ago
AMJEVITA (ADALIMUMAB-ATTO) — FDA approval
AMJEVITA
→
Jul 12, 2023
approval
$AMGN414.30-0.70%
3y ago
AMJEVITA (ADALIMUMAB-ATTO) — FDA approval
AMJEVITA
→
Aug 14, 2023
approval
$AMGN414.30-0.70%
3y ago
AMJEVITA (ADALIMUMAB-ATTO) — FDA approval
AMJEVITA
→
Aug 20, 2024
approval
$AMGN414.30-0.70%
2y ago
AMJEVITA (ADALIMUMAB-ATTO) — FDA approval
AMJEVITA
→
Apr 7, 2025
approval
$AMGN414.30-0.70%
1y ago
AMJEVITA (ADALIMUMAB-ATTO) — FDA approval
AMJEVITA
→
May 20, 2025
approval
$AMGN414.30-0.70%
1y ago
AMJEVITA (ADALIMUMAB-ATTO) — FDA approval
AMJEVITA
→
Sep 17, 2025
approval
$AMGN414.30-0.70%
11mo ago
AMJEVITA (ADALIMUMAB-ATTO) — FDA approval
AMJEVITA
→
Oct 16, 2025
approval
$AMGN414.30-0.70%
10mo ago
AMJEVITA (ADALIMUMAB-ATTO) — FDA approval
AMJEVITA
→
view all 13 catalysts →

News(5)

  • MoonLake’s nanobody boosts all clinical endpoints in phase 3 psoriatic arthritis trial
    MoonLake Immunotherapeutics announced positive phase 3 data for patients with psoriatic arthritis treated with its lead nanobody candidate, sonelokimab.
    fiercebiotech · 2d ago
  • AbbVie shares pressured as Q2 I&I beat falls below investor expectations
    AbbVie investors’ sky-high expectations led to a 4% share decline on Friday as the company reported more modest consensus beats than expected.
    biospace · 11d ago
  • cAMPfield lands $180M to build gut disease drug
    The biotech is advancing an anti-inflammatory drug that originated with vTv for inflammatory bowel diseases, leaning on a better side effect profile.
    biopharma_dive · 1mo ago
  • Biogen adds more immune drugs in $1B buyout of secretive startup RayThera
    The companies didn’t specify the drugs Biogen is acquiring in the deal, though patents RayThera secured provide important clues.
    biopharma_dive · 1mo ago
  • Opinion: The podcast telling the stories behind Ambien, Ozempic, EpiPens, and other game-changing drugs
    “We're basically not using our body as directed,” says "Drug Story" host Thomas Goetz.
    stat · 3mo ago
brand
AMJEVITA
trade names
Amgevita, Amsparity, Cyltezo, Halimatoz, Hefiya, Hulio
generic
ADALIMUMAB-ATTO
MOA
12.1 Mechanism of Action Adalimumab products bind specifically to TNF-alpha and block its interaction with the p55 and p75 cell surface TNF receptors. Adalimumab products also lyse surface TNF expressing cells in vitro in the presence of complement. Adalimumab products do not bind or inactivate lymphotoxin (TNF-beta). TNF is a naturally occurring cytokine that is involved in normal inflammatory and immune responses. Elevated concentrations of TNF are found in the synovial fluid of patients with RA, JIA, PsA, and AS and play an important role in both the pathologic inflammation and the joint destruction that are hallmarks of these diseases. Increased concentrations of TNF are also found in psoriasis plaques. In Ps, treatment with AMJEVITA may reduce the epidermal thickness and infiltration of inflammatory cells. The relationship between these pharmacodynamic activities and the mechanism(s) by which adalimumab products exert their clinical effects is unknown. Adalimumab products also modulate biological responses that are induced or regulated by TNF, including changes in the concentrations of adhesion molecules responsible for leukocyte migration (ELAM-1, VCAM-1, and ICAM-1 with an IC 50 of 1-2 × 10 -10 M).
phase
marketed
Data sources
openFDA · ClinicalTrials.gov · OpenTargets
last refreshed 5m ago
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