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  1. pharmadog
  2. ›drugs
  3. ›Imdelltra
drug
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tarlatamab

Marketedupdated 3mo ago
by $AMGN AMGEN INC
Approved
community read0 votes

🐶 often sniffed alongside

top 3
  • drugIMDELLTRA8 co-mentions · 2 sources
  • tagApproval8 co-mentions · 2 sources
  • company$AMGNAMGEN INC4 co-mentions · 2 sources

Antibody drug with a maximum clinical stage of Approval (across all indications), with 3 approved and 3 investigational indications.

all catalysts(2)

approval · 2
May 16, 2024
approval
$AMGN417.20+1.52%
2y ago
IMDELLTRA (TARLATAMAB-DLLE) — FDA approval
tarlatamab
→
Nov 19, 2025
approval
$AMGN417.20+1.52%
9mo ago
IMDELLTRA (TARLATAMAB-DLLE) — FDA approval
tarlatamab
→

Trials studying tarlatamab

  • phase2Study Investigating Tarlatamab (AMG 757) in Patients With Metastatic/Locally Advanced Small-Cell Lung Cancer (SCLC) and Other Poorly Differentiated Neuroendocrine Carcinomas (NECs), With Biomarker Analysis to Characterize Response/Resistance (UNLOCK TARLATAMAB)active not recruitingn=40
  • phase3A Study Comparing Tarlatamab, Durvalumab, Carboplatin, and Etoposide Versus Durvalumab, Carboplatin, and Etoposide in First-line Extensive Stage Small-Cell Lung Cancer (ES-SCLC)recruitingn=330
  • phase2Study Evaluating Tarlatamab in Chinese Participants With Advanced Small Cell Lung Cancer After Two or More Prior Lines of Treatmentactive not recruitingn=32
  • phase2A Trial of Tarlatamab in Patients With Pretreated Extensive-stage Small Cell Lung Cancer (ES-SCLC) and ECOG PS 2recruitingn=48
  • phase2A Study of Tarlatamab for People With Prostate Cancerrecruitingn=32
  • phase2Combination of Tarlatamab and Temozolomide in Patients With Central Nervous System Tumorsrecruitingn=70
  • phase1Study of Tarlatamab in Combination With YL201 With or Without Anti-programmed Death Ligand 1 (PD-L1) in Participants With Extensive Stage (ES) Small Cell Lung Cancer (SCLC)active not recruitingn=200
  • phase3Study Evaluating Tarlatamab After Chemoradiotherapy in Limited-Stage Small-Cell Lung Cancer (LS-SCLC)recruitingn=400
more trials →

News(0)

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brand
Imdelltra
generic
tarlatamab-dlle
MOA
12.1 Mechanism of Action Tarlatamab-dlle is a bispecific T-cell engager that binds to DLL3 expressed on the surface of cells, including tumor cells, and CD3 expressed on the surface of T cells. Tarlatamab-dlle causes T-cell activation, release of inflammatory cytokines, and lysis of DLL3-expressing cells. Tarlatamab-dlle had anti-tumor activity in mouse models of SCLC.
indication
Small-Cell Lung Cancer
phase
marketed
Data sources
openFDA · ClinicalTrials.gov
last refreshed 17m ago
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