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  1. pharmadog
  2. ›drugs
  3. ›IMDELLTRA
drug · antibody
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IMDELLTRA

updated 3mo ago
by $AMGN AMGEN INC🔗 ChEMBL
community read0 votes

🐶 often sniffed alongside

top 3
  • tagApproval8 co-mentions · 2 sources
  • drugtarlatamab8 co-mentions · 2 sources
  • company$AMGNAMGEN INC4 co-mentions · 2 sources

Antibody drug with a maximum clinical stage of Approval (across all indications), with 3 approved and 3 investigational indications.

targets

Delta-like protein 3T cell surface glycoprotein CD3

all catalysts(0)

nothing on the calendar yet

News(0)

no news has mentioned this drug yet

brand
IMDELLTRA
trade names
Imdelltra
generic
TARLATAMAB-DLLE
MOA
12.1 Mechanism of Action Tarlatamab-dlle is a bispecific T-cell engager that binds to DLL3 expressed on the surface of cells, including tumor cells, and CD3 expressed on the surface of T cells. Tarlatamab-dlle causes T-cell activation, release of inflammatory cytokines, and lysis of DLL3-expressing cells. Tarlatamab-dlle had anti-tumor activity in mouse models of SCLC.
indication
1 INDICATIONS AND USAGE IMDELLTRA is indicated for the treatment of adult patients with extensive stage small cell lung cancer (ES-SCLC) with disease progression on or after platinum-based chemotherapy. IMDELLTRA is a bispecific delta-like ligand 3 (DLL3)-directed CD3 T- cell engager indicated for the treatment of adult patients with extensive stage small cell lung cancer (ES-SCLC) with disease progression on or after platinum - based chemotherapy. ( 1 )
Data sources
ClinicalTrials.gov · OpenTargets
last refreshed 54m ago
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