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  1. pharmadog
  2. ›drugs
  3. ›MOUNJARO
drug · protein
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MOUNJARO

updated 5mo ago
/ tur-ZEP-ə-tyde /
by $LLY ELI LILLY & Co🔗 ChEMBL
community read0 votes

🐶 often sniffed alongside

top 6
  • drugtirzepatide112 co-mentions · 40 sources
  • drugZEPBOUND112 co-mentions · 40 sources
  • tagApproval96 co-mentions · 24 sources
  • companyEli Lilly and Co48 co-mentions · 24 sources
  • tagRecall16 co-mentions · 16 sources
  • drugcyanocobalamin2 co-mentions · 2 sources

Protein drug with a maximum clinical stage of Approval (across all indications), with 6 approved and 8 investigational indications.

targets

Glucagon-like peptide 1 receptorGastric inhibitory polypeptide receptor

all catalysts(0)

nothing on the calendar yet

Trials studying MOUNJARO

  • phase3Efficacy, Safety, and Pharmacokinetics of Tirzepatide (LY3298176) Once Weekly Versus Placebo in Pediatric Participants 6 to Less Than 12 Years of Age Who Have Obesity (ADVANCE-SURMOUNT-KIDS)not yet recruitingn=150
  • phase2Efficacy and Safety of Tirzepatide Versus Placebo or Lisdexamfetamine Dimesylate for Binge-Eating Disorderrecruitingn=105
  • phase3A Study of Tirzepatide in Adolescents With Obesity and Weight-Related Comorbidities (SURMOUNT-ADOLESCENTS-2)recruitingn=300
  • phase3A Research Study to See How Much CagriSema Lowers Blood Sugar and Body Weight Compared to Tirzepatide in People With Type 2 Diabetes Treated With Metformin With or Without an SGLT2 Inhibitorcompletedn=1,024
  • phase4Bariatric Surgery vs. Semaglutide vs. Tirzepatideactive not recruitingn=140
  • phase2A Study of SYH2069 Injection in Participants With T2DM Not Controlled With Diet/Exercise Alone or Metforminnot yet recruitingn=240
  • phase3Mirikizumab and Tirzepatide Administered in Adult Participants With Moderately to Severely Active Crohn's Disease and Obesity or Overweightrecruitingn=290
  • phase2A Study to Evaluate ALN-2232 in Participants With Obesityrecruitingn=156

News(10)

  • This week in charts: Kodiak’s big comeback and Hengrui’s dealmaking
    The latest installment in BioPharma Dive’s data visualization series features a closer look at Kodiak’s stock performance and Hengrui's ties with U.S. and European drugmakers.
    biopharma_dive · 2d ago
  • STAT+: Lilly bypasses Australian pharmacies with DTC model
    Eli Lilly is launching LillyDirect to deliver Mounjaro straight to Australian patients’ doors — and local doctors and pharmacists aren’t thrilled.
    stat · 2d ago
  • Kailera, Hengrui’s GLP-1/GIP candidate delivers weight, menstrual benefits to women with PMOS
    Kailera Therapeutics and Hengrui Pharma’s weekly injection showed benefits beyond weight loss in a mid-stage trial, leading to more regular menstrual cycles in patients with polyendocrine metabolic…
    biospace · 2d ago
  • 3 takeaways from a European obesity scientific meeting
    Eli Lilly impressed with its amylin-Zepbound combination data. Elsewhere, Novo demonstrated continued weight loss following a switch to oral and AbbVie and Boehringer gave glimpses into their conte…
    biopharma_dive · 3d ago
  • Fresenius Kabi manufacturing plant hit with FDA warning letter after adverse events
    Patients had adverse events after receiving a Fresenius Kabi medicine that experienced manufacturing deviations.
    biospace · 3d ago
  • STAT+: Pharmalittle: We’re reading about a plan to lower Medicare drug prices, a Lilly obesity drug, and more
    A final Medicare rule aimed at lowering prices for doctor-administered drugs applies to only four companies and saves 96% less than the initial proposal
    stat · 3d ago
  • Recon: Sanofi, Regeneron expand partnership after Dupixent success; Lilly amylin-Zepbound combo succeeds in mid-stage trial
    Welcome to Regulatory Reconnaissance, your regulatory news and intelligence briefing.
    raps · 4d ago
  • Superior weight loss, blood sugar control propel Lilly’s amylin-GIP/GLP-1 combo into Phase 3
    EloraTZP—a combination of an amylin asset and Eli Lilly’s approved obesity drug Zepbound—made a clean sweep of the primary and secondary endpoints in a mid-stage trial of adults with obesity and ty…
    biospace · 4d ago
  • #EASD26: Lilly's amylin-Zepbound combo posts best-ever weight loss in patients with obesity and diabetes
    MILAN — Forget Wegovy and Zepbound. Never mind CagriSema, and even retatrutide. The latest big name in obesity is eloraTZP. Data revealed Wednesday show that Lilly's amylin-incretin combination del…
    endpoints · 4d ago
  • STAT+: Eli Lilly’s Zepbound combined with amylin drug led to significant weight loss in mid-stage trial
    An investigational combination therapy from Eli Lilly led to significant weight loss in a mid-stage study, but high discontinuation rates raise questions about tolerability.
    stat · 4d ago
view all news mentions →
brand
MOUNJARO
trade names
Mounjaro, Mounjaro (autoinjector), Zepbound, Zepbound (autoinjector)
generic
TIRZEPATIDE
MOA
12.1 Mechanism of Action Tirzepatide is a GIP receptor and GLP-1 receptor agonist. It contains a C20 fatty diacid that enables albumin binding and prolongs the half-life. Tirzepatide selectively binds to and activates both the GIP and GLP-1 receptors, the targets for native GIP and GLP-1. Tirzepatide enhances first- and second-phase insulin secretion, and reduces glucagon levels, both in a glucose-dependent manner.
indication
1 INDICATIONS AND USAGE MOUNJARO ® is indicated as an adjunct to diet and exercise to improve glycemic control in adults and pediatric patients 10 years of age and older with type 2 diabetes mellitus. MOUNJARO ® is a glucose-dependent insulinotropic polypeptide (GIP) receptor and glucagon-like peptide-1 (GLP-1) receptor agonist indicated as an adjunct to diet and exercise to improve glycemic control in adults and pediatric patients 10 years of age and older with type 2 diabetes mellitus. ( 1 )
Data sources
ClinicalTrials.gov · OpenTargets
last refreshed 2h ago
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