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  1. pharmadog
  2. ›drugs
  3. ›EYLEA HD
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EYLEA HD

Marketedupdated 5mo ago
by $REGN REGENERON PHARMACEUTICALS, INC.🔗 ChEMBL
Approved
annual revenue · 2024–2024peak $9.4B
2024: $9.4B2024$9.4B
community read0 votes

🐶 often sniffed alongside

top 8
  • tagApproval44 co-mentions · 15 sources
  • drugEylea32 co-mentions · 15 sources
  • drugYESAFILI18 co-mentions · 7 sources
  • drugaflibercept biosimilar17 co-mentions · 10 sources
  • drugOPUVIZ8 co-mentions · 4 sources
  • drugENZEEVU6 co-mentions · 3 sources
  • companySamsung Bioepis Co Ltd4 co-mentions · 4 sources
  • companyBiocon Biologics Ltd4 co-mentions · 2 sources

Protein drug with a maximum clinical stage of Approval (across all indications), with 16 approved and 39 investigational indications.

indications

investigational
Diabetic Macular Edema

targets

Placenta growth factorVascular endothelial growth factor A, long form

all catalysts(5)

approval · 5
Aug 18, 2023
approval
$REGN757.53-3.87%
3y ago
EYLEA HD (AFLIBERCEPT) — FDA approval
EYLEA HD
→
Dec 14, 2023
approval
$REGN757.53-3.87%
3y ago
EYLEA HD (AFLIBERCEPT) — FDA approval
EYLEA HD
→
Oct 10, 2024
approval
$REGN757.53-3.87%
2y ago
EYLEA HD (AFLIBERCEPT) — FDA approval
EYLEA HD
→
Nov 19, 2025
approval
$REGN757.53-3.87%
10mo ago
EYLEA HD (AFLIBERCEPT) — FDA approval
EYLEA HD
→
Apr 2, 2026
approval
$REGN757.53-3.87%
6mo ago
EYLEA HD (AFLIBERCEPT) — FDA approval
EYLEA HD
→

Trials studying EYLEA HD

  • —An Observational Study to Collect Data on How Aflibercept (Eylea) Given Using a Paediatric Dosing Device is Used in Preterm Babies With Retinopathy of Prematurity in the United Kingdom (UK)recruitingn=200
  • phase3A Clinical Trial of EYE201/MK-8748 in People With Macular Degeneration (MK-8748-002)recruitingn=960
  • phase2A Study to Test Whether BI 764524 Helps People With an Eye Condition Called Diabetic Retinopathyactive not recruitingn=190
  • phase2Study of AR-14034 in Participants With Neovascular Age-Related Macular Degeneration (nAMD)active not recruitingn=139
  • phase3A Study to Evaluate the Efficacy and Safety of Tabirafusp Tedromer Compared to Aflibercept in Participants With DME - ALTOrecruitingn=910
  • phase3A Study to Evaluate Efficacy, Safety, and Immunogenicity With ABP 938 8 mg Versus EYLEA® HD (Aflibercept) in Participants With Neovascular Age-related Macular Degenerationrecruitingn=304
  • phase3Efficacy and Safety of LX102 Gene Therapy in Patients With Neovascular Age-related Macular Degeneration (nAMD) (STELLAR)recruitingn=388
  • phase3A 2-year Study of EYP-1901 in Subjects With Wet Age Related Macular Degeneration (wAMD) (LUCIA) Primary Efficacy Will be Determined at Week 56active not recruitingn=400

News(10)

  • Kodiak skyrockets on positive study data for 2 eye drugs
    The Phase 3 findings suggested Kodiak might have multiple threats to Regeneron’s Eylea and added more than $3 billion to the company’s market value.
    biopharma_dive · 4h ago
  • Kodiak's stock soars as it clinches crucial Phase 3 win for Eylea competitor
    Kodiak Sciences appears to have an Eylea successor on its hands. The Silicon Valley biotech said its experimental drug Zenkuda performed as well as Eylea in a progressive eye disease known as wet a…
    endpoints · 5h ago
  • Kodiak Sciences’ stock soars 166% after 2 assets match Eylea in Phase 3 trial
    Kodiak Sciences will head to regulators with one of the candidates, an anti-VEGF antibody called zenkuda, after the late-stage results.
    biospace · 5h ago
  • STAT+: AbbVie wins FDA nod for Parkinson’s pill
    The FDA has approved AbbVie’s once-daily Parkinson’s pill for sales, based on a late-stage study that showed the drug helped improve symptoms.
    stat · 6h ago
  • Kodiak's stock doubles as resurrected eye disease drug matches Eylea in phase 3
    Two of Kodiak Sciences’ drug candidates have matched aflibercept in a phase 3 clinical trial, positioning the biotech to seek FDA approval of one of the eye disease assets this year.
    fiercebiotech · 12h ago
  • Merck sees pivotal victory for $3B eye disease prospect
    Merck & Co.’s Brunello trial has hit its primary endpoint, shedding light on the effects of a trispecific diabetic macular edema (DME) drug candidate that the Big Pharma bought in a $3 billion take…
    fiercebiotech · 4d ago
  • Regeneron to challenge Ipsen as FDA clears bone disease drug
    Pasatru’s approval sets up a market battle in a rare indication where the only available treatment has generated disappointing sales.
    biopharma_dive · 1mo ago
  • EyePoint’s bid to compete with Eylea falls flat
    EyePoint’s experimental eye treatment came up short of Eylea, the current go-to option for wet age-related macular degeneration, according to results of a Phase 3 trial. The company’s shares {$EYPT…
    endpoints · 1mo ago
  • EyePoint plummets on pivotal data for main drug
    Though its drug missed the key goal of a wet AMD study, EyePoint — as well as analysts — see a path toward approval. Investors may be harder to win over, however.
    biopharma_dive · 1mo ago
  • EyePoint’s Phase 3 fail sends stock spiraling amid next-gen AMD race
    EyePoint’s quest to reduce treatment burden for patients with age-related macular degeneration has hit a bump in the road, with a clinical miss driving the biotech’s stock down by 70%.
    biospace · 1mo ago
view all news mentions →
brand
EYLEA HD
trade names
Eylea, Yesafili, Zaltrap
generic
AFLIBERCEPT
MOA
12.1 Mechanism of Action Vascular endothelial growth factor-A (VEGF-A) and placental growth factor (PlGF) are members of the VEGF family of angiogenic factors that can act as mitogenic, chemotactic, and vascular permeability factors for endothelial cells. VEGF acts via two receptor tyrosine kinases, VEGFR-1 and VEGFR-2, present on the surface of endothelial cells. PlGF binds only to VEGFR-1, which is also present on the surface of leucocytes. Activation of these receptors by VEGF-A can result in neovascularization and vascular permeability. Aflibercept acts as a soluble decoy receptor that binds VEGF-A and PlGF, and thereby can inhibit the binding and activation of these cognate VEGF receptors.
indication
wet AMD, diabetic macular edema, retinal vein occlusion
phase
marketed
approved
2011-11-18
Data sources
openFDA · ClinicalTrials.gov · OpenTargets
last refreshed 1h ago
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