drug · small molecule

EPINEPHRINE

Phase 2updated 2mo ago

by $AMRX Amneal Pharmaceuticals, Inc.🔗 ChEMBL

Phase 2

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Small molecule drug with a maximum clinical stage of Approval (across all indications), with 19 approved and 33 investigational indications.

targets

Adrenergic receptor

all catalysts(0)

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brand

EPINEPHRINE

trade names

Adren co, Adrenaclick, Adrenalin, Ana-guard, Ana-kit, Anapen

generic

EPINEPHRINE

MOA

12.1 Mechanism of Action Epinephrine acts on both alpha (α)- and beta (β)-adrenergic receptors. The mechanism of the rise in blood pressure is 3-fold: a direct myocardial stimulation that increases the strength of ventricular contraction (positive inotropic action), an increased heart rate (positive chronotropic action), and peripheral vasoconstriction.

indication

1 INDICATIONS AND USAGE Epinephrine is a non-selective alpha and beta adrenergic agonist indicated to increase mean arterial blood pressure in adult patients with hypotension associated with septic shock. ( 1.1 ) 1.1 Hypotension associated with Septic Shock Epinephrine Injection USP, 1 mg/10 mL (0.1 mg/mL) is indicated to increase mean arterial blood pressure in adult patients with hypotension associated with septic shock.

phase

phase_2

EPINEPHRINE

targets

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Trials studying EPINEPHRINE