drug · small molecule

DEPAKOTE ER

updated 3mo ago

by $ABBV AbbVie Inc.🔗 ChEMBL

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Small molecule drug with a maximum clinical stage of Approval (across all indications), with 9 approved and 15 investigational indications.

targets

Succinate-semialdehyde dehydrogenase, mitochondrial

all catalysts(0)

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Trials studying DEPAKOTE ER

phase2Neratinib + Valproate in Advanced Solid Tumors, w/Expansion Cohort in Ras-Mutated Carecruitingn=83
phase4Does The Addition Of Divalproex Sodium ER To An Atypical Antipsychotic Drug (APD) Improve Cognition And Psychopathology In Outpatients With Schizophrenia (SCH) Or Schizoaffective Disorder (SAD)?completedn=60

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brand

DEPAKOTE ER

trade names

Depakote, Depakote cp, Depakote er, Divalproex sodium

generic

DIVALPROEX SODIUM

MOA

12.1 Mechanism of Action Divalproex sodium dissociates to the valproate ion in the gastrointestinal tract. The mechanisms by which valproate exerts its therapeutic effects have not been established. It has been suggested that its activity in epilepsy is related to increased brain concentrations of gamma-aminobutyric acid (GABA).

indication

1 INDICATIONS AND USAGE Depakote ER is indicated for: Acute treatment of manic or mixed episodes associated with bipolar disorder, with or without psychotic features ( 1.1 ) Monotherapy and adjunctive therapy of complex partial seizures and simple and complex absence seizures; adjunctive therapy in patients with multiple seizure types that include absence seizures ( 1.2 ) Prophylaxis of migraine headaches ( 1.3 ) 1.1 Mania Depakote ER is a valproate and is indicated for the treatment of acute manic or mixed episodes associated with bipolar disorder, with or without psychotic features. A manic episode is a distinct period of abnormally and persistently elevated, expansive, or irritable mood. Typical symptoms of mania include pressure of speech, motor hyperactivity, reduced need for sleep, flight of ideas, grandiosity, poor judgment, aggressiveness, and possible hostility. A mixed episode is characterized by the criteria for a manic episode in conjunction with those for a major depressive episode (depressed mood, loss of interest or pleasure in nearly all activities). The efficacy of Depakote ER is based in part on studies of Depakote (divalproex sodium delayed release tablets) in this indication, and was confirmed in a 3-week trial with patients meeting DSM-IV TR criteria for bipolar I disorder, manic or mixed type, who were hospitalized for acute mania [see Clinical Studies ( 14.1 ) ] . The effectiveness of valproate for long-term use in mania, i.e., more than 3 weeks, has not been demonstrated in controlled clinical trials. Therefore, healthcare providers who elect to use Depakote ER for extended periods should continually reevaluate the long-term risk-benefits of the drug for the individual patient. 1.2 Epilepsy Depakote ER is indicated as monotherapy and adjunctive therapy in the treatment of adult patients and pediatric patients down to the age of 10 years with complex partial seizures that occur either in isolation or in association with other types of seizures

Data sources

ClinicalTrials.gov · OpenTargets

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drug · small molecule

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DEPAKOTE ER

updated 3mo ago

by $ABBV AbbVie Inc.🔗 ChEMBL

community read0 votes

🐶 often sniffed alongside

top 8

Small molecule drug with a maximum clinical stage of Approval (across all indications), with 9 approved and 15 investigational indications.

targets

Succinate-semialdehyde dehydrogenase, mitochondrial

all catalysts(0)

nothing on the calendar yet

Trials studying DEPAKOTE ER

News(0)

no news has mentioned this drug yet

brand

DEPAKOTE ER

trade names

Depakote, Depakote cp, Depakote er, Divalproex sodium

generic

DIVALPROEX SODIUM

MOA

indication

Data sources

ClinicalTrials.gov · OpenTargets

last refreshed 49m ago

Found something off?

comments(0)

5-min edit window · permanent after that

no comments yet — first sniff?

DEPAKOTE ER

🐶 often sniffed alongside

targets

all catalysts(0)

Trials studying DEPAKOTE ER

News(0)

Report a data issue

comments(0)

DEPAKOTE ER

🐶 often sniffed alongside

targets

all catalysts(0)

Trials studying DEPAKOTE ER

News(0)

Report a data issue

comments(0)