drug · small molecule

DEPAKOTE

updated 3mo ago

by $ABBV AbbVie Inc.🔗 ChEMBL

community read0 votes

🐶 often sniffed alongside

top 8

Small molecule drug with a maximum clinical stage of Approval (across all indications), with 9 approved and 15 investigational indications.

targets

Succinate-semialdehyde dehydrogenase, mitochondrial

all catalysts(0)

nothing on the calendar yet

Trials studying DEPAKOTE

phase2Neratinib + Valproate in Advanced Solid Tumors, w/Expansion Cohort in Ras-Mutated Carecruitingn=83
phase4Does The Addition Of Divalproex Sodium ER To An Atypical Antipsychotic Drug (APD) Improve Cognition And Psychopathology In Outpatients With Schizophrenia (SCH) Or Schizoaffective Disorder (SAD)?completedn=60

News(0)

no news has mentioned this drug yet

brand

DEPAKOTE

trade names

Depakote, Depakote cp, Depakote er, Divalproex sodium

generic

DIVALPROEX SODIUM

MOA

12.1 Mechanism of Action Divalproex sodium dissociates to the valproate ion in the gastrointestinal tract. The mechanisms by which valproate exerts its therapeutic effects have not been established. It has been suggested that its activity in epilepsy is related to increased brain concentrations of gamma-aminobutyric acid (GABA).

indication

1 INDICATIONS AND USAGE Depakote is an anti-epileptic drug indicated for: Treatment of manic episodes associated with bipolar disorder ( 1.1 ) Monotherapy and adjunctive therapy of complex partial seizures and simple and complex absence seizures; adjunctive therapy in patients with multiple seizure types that include absence seizures ( 1.2 ) Prophylaxis of migraine headaches ( 1.3 ) 1.1 Mania Depakote (divalproex sodium) is a valproate and is indicated for the treatment of the manic episodes associated with bipolar disorder. A manic episode is a distinct period of abnormally and persistently elevated, expansive, or irritable mood. Typical symptoms of mania include pressure of speech, motor hyperactivity, reduced need for sleep, flight of ideas, grandiosity, poor judgment, aggressiveness, and possible hostility. The efficacy of Depakote was established in 3-week trials with patients meeting DSM-III-R criteria for bipolar disorder who were hospitalized for acute mania [see Clinical Studies ( 14.1 ) ] . The safety and effectiveness of Depakote for long-term use in mania, i.e., more than 3 weeks, has not been demonstrated in controlled clinical trials. Therefore, healthcare providers who elect to use Depakote for extended periods should continually reevaluate the long-term usefulness of the drug for the individual patient. 1.2 Epilepsy Depakote is indicated as monotherapy and adjunctive therapy in the treatment of patients with complex partial seizures that occur either in isolation or in association with other types of seizures. Depakote is also indicated for use as sole and adjunctive therapy in the treatment of simple and complex absence seizures, and adjunctively in patients with multiple seizure types that include absence seizures. Simple absence is defined as very brief clouding of the sensorium or loss of consciousness accompanied by certain generalized epileptic discharges without other detectable clinical signs. Complex absence is the term used when other signs

Data sources

ClinicalTrials.gov · OpenTargets

last refreshed 18m ago

Found something off?

comments(0)

5-min edit window · permanent after that

no comments yet — first sniff?

drug · small molecule

save

DEPAKOTE

updated 3mo ago

by $ABBV AbbVie Inc.🔗 ChEMBL

community read0 votes

🐶 often sniffed alongside

top 8

Small molecule drug with a maximum clinical stage of Approval (across all indications), with 9 approved and 15 investigational indications.

targets

Succinate-semialdehyde dehydrogenase, mitochondrial

all catalysts(0)

nothing on the calendar yet

Trials studying DEPAKOTE

News(0)

no news has mentioned this drug yet

brand

DEPAKOTE

trade names

Depakote, Depakote cp, Depakote er, Divalproex sodium

generic

DIVALPROEX SODIUM

MOA

indication

Data sources

ClinicalTrials.gov · OpenTargets

last refreshed 18m ago

Found something off?

comments(0)

5-min edit window · permanent after that

no comments yet — first sniff?

DEPAKOTE

🐶 often sniffed alongside

targets

all catalysts(0)

Trials studying DEPAKOTE

News(0)

Report a data issue

comments(0)

DEPAKOTE

🐶 often sniffed alongside

targets

all catalysts(0)

Trials studying DEPAKOTE

News(0)

Report a data issue

comments(0)