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  2. ›drugs
  3. ›CYCLOSPORINE
drug · protein
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CYCLOSPORINE

Phase 3updated 2mo ago
by $AMRX Amneal Pharmaceuticals, Inc.🔗 ChEMBL
Phase 3
community read0 votes

🐶 often sniffed alongside

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Protein drug with a maximum clinical stage of Approval (across all indications), with 12 approved and 71 investigational indications.

targets

Peptidyl-prolyl cis-trans isomerase A

all catalysts(0)

nothing on the calendar yet

Trials studying CYCLOSPORINE

  • phase4Efficacy of Vevye Ophthalmic Solution for the Treatment of Meibomian Gland Dysfunctionrecruitingn=48
  • phase4Comparison of Conjunctival Goblet Cell Density in Dry Eye Patients Treated With Cyclosporine 0.1% Dissolved in Perfluorobutylpentane (Vevye®) or Generic 0.05% Cyclosporine Emulsion for 8 Weeksnot yet recruitingn=60
  • —Real-World Assessment of VEVYE® for Short-Term Symptom and Sign Improvement of Dry Eye Disease in a Neuro-Ophthalmology Clinic: A 6-Month Prospective Observational Studyrecruitingn=50
  • phase3Extension Trial on Efficacy / Safety of L-CsA + SoC in Treating BOS in Post Single or Double Lung Transplant (BOSTON-3)terminatedn=164
  • phase2Ruxolitinib Based GVHD Prophylaxis Regimen Before, During, and After Hematopoietic Cell Transplantation in Older Adult Patients With Acquired Aplastic Anemiarecruitingn=20
  • phase2Donor Stem Cell Transplant With Treosulfan, Fludarabine, and Total-Body Irradiation for the Treatment of Hematological Malignanciesrecruitingn=60
  • phase3Efficacy + Safety of Liposome Cyclosporine A to Treat Bronchiolitis Obliterans Post Double Lung Transplant (BOSTON-2)completedn=169
  • phase3A Study to Evaluate the Benefits and Risks of Conversion of Existing Adolescent Kidney Transplant Recipients Aged 12 to <18 Years to a Belatacept-based Immunosuppressive Regimen as Compared to Continuation of a Calcineurin Inhibitor-based Regimen, and Their Adherence to Immunosuppressive Medicationsrecruitingn=102
more trials →

News(0)

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brand
CYCLOSPORINE
trade names
Capimune, Capsorin, Cequa, Cyclosporine, Deximune, Gengraf
generic
CYCLOSPORINE
MOA
Cyclophilin A modulator
indication
INDICATIONS AND USAGE Kidney, Liver, and Heart Transplantation Cyclosporine capsules (modified) is indicated for the prophylaxis of organ rejection in kidney, liver, and heart allogeneic transplants. Cyclosporine capsules (modified) has been used in combination with azathioprine and corticosteroids. Rheumatoid Arthritis Cyclosporine capsules (modified) is indicated for the treatment of patients with severe active, rheumatoid arthritis where the disease has not adequately responded to methotrexate. Cyclosporine capsules (modified) can be used in combination with methotrexate in rheumatoid arthritis patients who do not respond adequately to methotrexate alone. Psoriasis Cyclosporine capsules (modified) is indicated for the treatment of adult, nonimmunocompromised patients with severe (i.e., extensive and/or disabling), recalcitrant, plaque psoriasis who have failed to respond to at least one systemic therapy (e.g., PUVA, retinoids, or methotrexate) or in patients for whom other systemic therapies are contraindicated, or cannot be tolerated. While rebound rarely occurs, most patients will experience relapse with cyclosporine capsules (modified) as with other therapies upon cessation of treatment.
phase
phase_3
Data sources
ClinicalTrials.gov · OpenTargets
last refreshed 4m ago
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