drug · protein

CYCLOSPORINE

Phase 3updated 2mo ago

by $AMRX Amneal Pharmaceuticals, Inc.🔗 ChEMBL

Phase 3

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Protein drug with a maximum clinical stage of Approval (across all indications), with 12 approved and 71 investigational indications.

targets

Peptidyl-prolyl cis-trans isomerase A

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brand

CYCLOSPORINE

trade names

Capimune, Capsorin, Cequa, Cyclosporine, Deximune, Gengraf

generic

CYCLOSPORINE

MOA

Cyclophilin A modulator

indication

INDICATIONS AND USAGE Kidney, Liver, and Heart Transplantation Cyclosporine capsules (modified) is indicated for the prophylaxis of organ rejection in kidney, liver, and heart allogeneic transplants. Cyclosporine capsules (modified) has been used in combination with azathioprine and corticosteroids. Rheumatoid Arthritis Cyclosporine capsules (modified) is indicated for the treatment of patients with severe active, rheumatoid arthritis where the disease has not adequately responded to methotrexate. Cyclosporine capsules (modified) can be used in combination with methotrexate in rheumatoid arthritis patients who do not respond adequately to methotrexate alone. Psoriasis Cyclosporine capsules (modified) is indicated for the treatment of adult, nonimmunocompromised patients with severe (i.e., extensive and/or disabling), recalcitrant, plaque psoriasis who have failed to respond to at least one systemic therapy (e.g., PUVA, retinoids, or methotrexate) or in patients for whom other systemic therapies are contraindicated, or cannot be tolerated. While rebound rarely occurs, most patients will experience relapse with cyclosporine capsules (modified) as with other therapies upon cessation of treatment.

phase

phase_3

CYCLOSPORINE

targets

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