drug · small molecule

CABOMETYX

Phase 3updated 3mo ago

by $EXEL EXELIXIS, INC.🔗 ChEMBL

Phase 3

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Small molecule drug with a maximum clinical stage of Approval (across all indications), with 3 approved and 9 investigational indications.

targets

Hepatocyte growth factor receptorVascular endothelial growth factor receptor 2

all catalysts(0)

nothing on the calendar yet

Trials studying CABOMETYX

phase1Cabozantinib in Combination With Enfortumab Vedotin for Locally Advanced or Metastatic Urothelial Cancerrecruitingn=32
phase2Cabozantinib With Radiation Therapy for the Treatment of Sarcomas of the Extremitiesterminatedn=6

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brand

CABOMETYX

trade names

Cabometyx, Cometriq

generic

CABOZANTINIB S-MALATE

MOA

12.1 Mechanism of Action In vitro biochemical and/or cellular assays have shown that cabozantinib inhibits the tyrosine kinase activity of MET, VEGFR-1, -2 and -3, AXL, RET, ROS1, TYRO3, MER, KIT, TRKB, FLT-3, and TIE-2. These receptor tyrosine kinases are involved in both normal cellular function and pathologic processes such as oncogenesis, metastasis, tumor angiogenesis, drug resistance, and maintenance of the tumor microenvironment.

indication

1 INDICATIONS AND USAGE CABOMETYX is a kinase inhibitor indicated for the treatment of patients with advanced renal cell carcinoma (RCC). ( 1.1 ) patients with advanced renal cell carcinoma, as a first-line treatment in combination with nivolumab ( 1.1 ) patients with hepatocellular carcinoma (HCC) who have been previously treated with sorafenib ( 1.2 ) adult and pediatric patients 12 years of age and older with locally advanced or metastatic differentiated thyroid cancer (DTC) that has progressed following prior VEGFR-targeted therapy and who are radioactive iodine-refractory or ineligible ( 1.3 ) adult and pediatric patients 12 years of age and older with previously treated, unresectable, locally advanced or metastatic, well-differentiated pancreatic neuroendocrine tumors (pNET). ( 1.4 ) adult and pediatric patients 12 years of age and older with previously treated, unresectable, locally advanced or metastatic, well-differentiated extra-pancreatic neuroendocrine tumors (epNET). ( 1.4 ) 1.1 Renal Cell Carcinoma CABOMETYX is indicated for the treatment of patients with advanced renal cell carcinoma (RCC). CABOMETYX, in combination with nivolumab, is indicated for the first-line treatment of patients with advanced RCC. 1.2 Hepatocellular Carcinoma CABOMETYX is indicated for the treatment of patients with hepatocellular carcinoma (HCC) who have been previously treated with sorafenib. 1.3 Differentiated Thyroid Cancer CABOMETYX is indicated for the treatment of adult and pediatric patients 12 years of age and older with locally advanced or metastatic differentiated thyroid cancer (DTC) that has progressed following prior VEGFR-targeted therapy and who are radioactive iodine-refractory or ineligible. 1.4 Neuroendocrine Tumors CABOMETYX is indicated for the treatment of adult and pediatric patients 12 years of age and older with previously treated, unresectable, locally advanced or metastatic, well-differentiated pancreatic neuroendocrine tumors (pNET). CABOMETYX is indi

phase

phase_3

Data sources

ClinicalTrials.gov · OpenTargets

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CABOMETYX

Phase 3updated 3mo ago

by $EXEL EXELIXIS, INC.🔗 ChEMBL

Phase 3

community read0 votes

🐶 often sniffed alongside

top 8

Small molecule drug with a maximum clinical stage of Approval (across all indications), with 3 approved and 9 investigational indications.

targets

Hepatocyte growth factor receptorVascular endothelial growth factor receptor 2

all catalysts(0)

nothing on the calendar yet

Trials studying CABOMETYX

phase1Cabozantinib in Combination With Enfortumab Vedotin for Locally Advanced or Metastatic Urothelial Cancerrecruitingn=32
phase2Cabozantinib With Radiation Therapy for the Treatment of Sarcomas of the Extremitiesterminatedn=6

News(0)

no news has mentioned this drug yet

brand

CABOMETYX

trade names

Cabometyx, Cometriq

generic

CABOZANTINIB S-MALATE

MOA

indication

phase

phase_3

Data sources

ClinicalTrials.gov · OpenTargets

last refreshed 14m ago

Found something off?

comments(0)

5-min edit window · permanent after that

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CABOMETYX

🐶 often sniffed alongside

targets

all catalysts(0)

Trials studying CABOMETYX

News(0)

Report a data issue

comments(0)

CABOMETYX

🐶 often sniffed alongside

targets

all catalysts(0)

Trials studying CABOMETYX

News(0)

Report a data issue

comments(0)