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PUBLIC COMPANY
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$IONSIONIS PHARMACEUTICALS INC

$IONS43.54-1.05%
Carlsbad, CA, USupdated 17h ago

Ionis Pharmaceuticals, Inc. is a biotechnology company that specializes in discovering and developing antisense therapy, as well as RNA interference and CRISPR therapeutics. The company was founded in 1989 is based in Carlsbad, California. The company was previously known as Isis Pharmaceuticals until December 2015.

Website ↗SEC EDGAR ↗Yahoo Finance ↗
community read0 votes
pipeline
7
marketed
2
phase 3
1
catalysts ytd
2
approvals ytd
0
recalls ytd
0

Pipeline(7)

pipeline depth7 products
Phase 2: 3Phase 3: 1Marketed: 2pre_registration: 1
3Phase 21Phase 32Marketed1pre_registration
Marketed
donidalorsen sodium
Hereditary Angioedema (HAE) (C1 Esterase Inhibitor [C1-IN…
Marketed
olezarsen sodium
Hypertriglyceridemia
Phase 3
obudanersen sodium
Angelman Syndrome
Phase 2
ION-283
Lafora Disease (Unverricht Disease)
Phase 2
ION-356
Pelizaeus-Merzbacher Disease (PMD)
Phase 2
vadernersen sodium
X Chromosome Disorders
pre_registration
zilganersen sodium
Alexander Disease

📅 Upcoming

no upcoming catalysts on record

🕒 Recent(90d)

earnings (1)
Jul 29, 2026
earnings
$IONS43.54-1.05%
2mo ago
IONIS PHARMACEUTICALS INC earnings
IONIS PHARMACEUTICALS INC
→
view all catalysts →

Insider activity

source: SEC Form 4

open-market buys + sells

  • Apr 16, 26SELLBaroldi Joseph· EVP, Chief Business Officer5,619 sh @ $74.56−$419K↗
  • Apr 16, 26SELLJenne Kyle· EVP, Chf GL Pdt Str Ofcr4,902 sh @ $75.17−$368K↗
  • Apr 16, 26SELLBirchler Brian· EVP, Corp and Development Ops973 sh @ $75.04−$73K↗
  • Apr 15, 26SELLPARSHALL B LYNNE· director4,466 sh @ $76.19−$340K↗
  • Apr 15, 26SELLPARSHALL B LYNNE· director534 sh @ $76.97−$41K↗
routine RSU / option mechanics (6)
  • Apr 15, 26option exerciseBaroldi Joseph · EVP, Chief Business Officer10,837 sh
  • Apr 15, 26option exerciseBaroldi Joseph · EVP, Chief Business Officer10,837 sh
  • Apr 15, 26option exerciseJenne Kyle · EVP, Chf GL Pdt Str Ofcr12,226 sh
  • Apr 15, 26option exerciseJenne Kyle · EVP, Chf GL Pdt Str Ofcr12,226 sh
  • Apr 15, 26option exerciseBirchler Brian · EVP, Corp and Development Ops1,875 sh
  • Apr 15, 26option exerciseBirchler Brian · EVP, Corp and Development Ops1,875 sh
🐶 Hiring Signal
No open roles indexed yet — view IONIS PHARMACEUTICALS INC jobs →

News

  • Novartis wagers almost $8B on a Chinese biotech’s RNA drugs
    In exchange for a $575 million payment up front, Abogen Biosciences will furnish Novartis with access to its RNA technology, including an option to license its lead program ABO-2203.
    biopharma_dive · 2d ago
  • Lawmakers hear mixed opinions on psychedelics credentialing
    As psychedelic drugs inch closer to commercialization, two House lawmakers are charting a path forward for their inevitable rollout and what any potential accompanying legislation could focus on. T…
    endpoints · 3d ago
  • RNAi drug specialist ADARx raises $446M IPO
    ADARx is the only maker of RNA-based drugs to go public since 2024 and the first RNAi biotech to price an IPO in the U.S. in more than a decade.
    biopharma_dive · 9d ago
  • Lilly’s latest China drug deal; Immunovant’s setback in lupus
    Lilly wagered up to $3.35 billion in its fourth China-focused alliance since January 2025. Elsewhere, analysts are now more confident about one of Vertex’s top prospects and an RNA drug succeeded a…
    biopharma_dive · 10d ago
  • Roche, Ionis RNA drug scores in kidney disease study
    The results position Roche to bring a new kind of medicine to market for IgA nephropathy, a disease that’s drawn considerable attention of late from drugmakers.
    biopharma_dive · 10d ago
  • Roche-Ionis’ RNA therapy reduces kidney disease marker, opening path to swift FDA nod
    A late-stage test of Roche and Ionis Pharmaceuticals’ sefaxersen showed that the drug reduced protein in the urine, which suggests the RNA-targeting therapy could improve kidney function and delay…
    biospace · 11d ago
  • Ionis-Otsuka offer 'groundbreaking' improvement in function and survival for genetic type of ALS
    Ulefnersen, an RNA-targeted therapy being developed by Ionis Pharmaceuticals and Otsuka Pharmaceutical, improved measurements of functional impairment and survival in patients with a rare, genetic…
    biospace · 11d ago
  • Roche’s phase 3 win tees up fight with Novartis for blockbuster kidney disease market
    Roche has reported a phase 3 win for sefaxersen in kidney disease, teeing up talks with regulators about the path to approval for the Ionis-partnered, would-be blockbuster candidate.
    fiercebiotech · 11d ago
  • Otsuka heads to FDA as Ionis-partnered ALS drug hits primary phase 3 endpoint
    A phase 3 study of Otsuka and Ionis Pharmaceuticals’ amyotrophic lateral sclerosis drug candidate has hit its primary endpoint, positioning the partners to talk to regulators about expedited approv…
    fiercebiotech · 12d ago
  • Cellectis quits CAR-T and pivots to ‘in vivo’ gene editing
    Long a frontrunner in donor-derived cell therapy research, the French biotech cited a shifting landscape in changing course and choosing to offload its lead programs.
    biopharma_dive · 19d ago
view all news mentions →
identifiers
ticker
$IONS
SEC CIK
0000874015
country
US
source
sec_tickers
top tags
Immunology1
mentioned in
10news items
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Data sources
SEC EDGAR · openFDA
last refreshed 20m ago
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