Tegoprazan-Aspirin Drug Interaction in Healthy Adult Male Volunteers
brief summary
This Clinical Trial Aims to Evaluate the PK/PD Drug-Drug Interaction and Safety/Tolerability of Tegoprazan and Aspirin in Healthy Adult Male Volunteers.
detailed description
Trial Objective
1. Primary Objective
* To evaluate the effect of Tegoprazan on the PK and PD of Aspirin following coadministration of Tegoprazan and Aspirin in healthy male adult participants. * To evaluate the effect of Aspirin on the PK of Tegoprazan following coadministration of Tegoprazan and Aspirin in healthy male adult participants. 2. Secondary Objective
* To evaluate the safety and tolerability of Tegoprazan and Aspirin when coadministered in healthy male adult participants. 3. Exploratory Objective
* To perform an exploratory evaluation of the concentrations and interconversion characteristics of isomers(R-form and S-form) in blood to explore the in vivo biotransformation profile of Tegoprazan and its metabolites in healthy male adult participants.
official title
An Open-label, Single-sequence, 3-periods, 3-treatments, Phase I Clinical Trial to Evaluate the Pharmacokinetic/Pharmacodynamic Drug-drug Interaction and Safety/Tolerability Between Tegoprazan and Aspirin in Healthy Male Adult Volunteers