Investigating the Effect of Itraconazole on the Pharmacokinetics of AZD4144 in Healthy Participants
brief summary
The purpose of the study is to assess the pharmacokinetics (PK) of AZD4144 when administered alone and in combination with itraconazole in healthy participants.
detailed description
This is an open-label, randomised, two arm, 3 period, fixed sequence study in healthy participants.
The study will include two parallel, independent arms with one arm evaluating oral administration of AZD4144 and the other evaluating AZD4144 administered as an intravenous (IV) infusion.
Each study arm will comprise of:
1. A screening period of up to 28 days. 2. Three treatment periods during which participants will receive AZD4144 alone, itraconazole alone, and AZD4144 in combination with itraconazole. 3. A final follow-up visit.
official title
An Open-label, Randomised, Two Arm, Fixed Sequence Study in Healthy Participants to Assess the Pharmacokinetics of AZD4144 When Administered Alone and in Combination With Itraconazole