clinical trial · NCT07661108
A Clinical Study of MK-8527 in Healthy Participants (MK-8527-021)
Merck Sharp & Dohme LLC·phase1·active not recruiting·n = 44
HealthyMK-8527ProbenecidItraconazole
brief summary
Researchers are studying a medicine called MK-8527 to learn how it behaves in the body of healthy adults. The goal of this study is to learn about the effect of MK-8527 when it is taken with food or with other medicines. Researchers also want to learn about the safety of MK-8527 and if people tolerate it. Tolerate means participants will receive treatment in the trial unless they need to stop it due to health problems.
started
Jun 30, 2026
primary completion
Oct 9, 2026
completion
Oct 9, 2026
last updated
Sep 3, 2026
official title
An Open-label, Phase 1 Study to Individually Characterize the Food Effect, the Drug-Drug Interaction Effect of OAT Inhibition, and the Drug-Drug Interaction Effect of P-glycoprotein Inhibition on the Pharmacokinetics of MK-8527 in Healthy Adult Participants
sourced from ClinicalTrials.gov · pharmadog mirrors structured fields, not the full protocol