clinical trial · NCT07596485
RP-008 in Combination With Daily Oral Varenicline for the Treatment of Trigeminal Neuralgia
Kriya Therapeutics, Inc.·phase2·recruiting·n = 24
Trigeminal NeuralgiaRP-008Varenicline tartrate
brief summary
The goal of this study is to evaluate if KRIYA-748 (RP-008) is safe, tolerable, and preliminary effective in treating trigeminal neuralgia (TN) when used in combination with varenicline tartrate. The study will also assess what doses of RP-008 are safe and tolerable for participants and how the severity of participants' TN pain and frequency of facial pain attacks are affected.
started
Jun 1, 2026
primary completion
Dec 1, 2028
completion
Dec 1, 2028
last updated
May 19, 2026
official title
A Phase 1/2, Multicenter, Open-Label Study to Evaluate Safety, Tolerability, and PRELIminary EFficacy of Percutaneous Injection of RP-008 Followed by Daily Oral Varenicline in Patients With Trigeminal Neuralgia (The RELIEF Study)
sourced from ClinicalTrials.gov · pharmadog mirrors structured fields, not the full protocol