clinical trial · NCT07509307
AMAZE 6: A Research Study Investigating How Well the Medicine NNC0487-0111 Helps People With Excess Body Weight and Knee Osteoarthritis Lose Weight and Reduce Pain
Novo Nordisk A/S·phase3·recruiting·n = 400
ObesityOverweightOsteoarthritis, KneeNNC0487-0111Placebo (matched to NNC0487-0111)
brief summary
This study is being done to look at the safety and effect of NNC0487-0111 in people with excess body weight and knee osteoarthritis when compared to placebo. There are 2 study treatments in this study taken as injections under the skin once a week. Participants will either get NNC0487-0111, (the treatment being tested) or Placebo (a treatment that has no active medicine in it). Which treatment participants get is decided by chance.
started
Apr 20, 2026
primary completion
Aug 14, 2028
completion
Aug 14, 2028
last updated
Jun 2, 2026
official title
Efficacy and Safety of NNC0487-0111 s.c. Once-weekly in Participants With Overweight or Obesity, and Knee Osteoarthritis (AMAZE 6)
sourced from ClinicalTrials.gov · pharmadog mirrors structured fields, not the full protocol