clinical trial · NCT07282093
Pharmacokinetics of Olverembatinib in Participants With Hepatic Impairment
PharmacokineticOlverembatinibOlverembatinib 20mg
brief summary
This is a non-randomized, open-label, parallel, single-dose study to evaluate the pharmacokinetic profile of olverembatinib in participants with normal or impaired liver function.
started
Nov 11, 2025
primary completion
Jun 30, 2026
completion
Oct 31, 2026
last updated
Dec 23, 2025
detailed description
To evaluate the PK characteristics of olverembatinib in participants with mild hepatic impairment (Child-Pugh Class A), moderate hepatic impairment (Child-Pugh Class B), severe hepatic impairment (Child-Pugh Class C) and sex, age, and body weight-matched healthy participants with normal hepatic function, so as to provide a scientific basis for the appropriate dose and/or dosing interval adjustment in participants with hepatic impairment.
official title
An Open-Label, Phase 1 Study to Investigate the Effect of Hepatic Impairment on the Pharmacokinetics of Olverembatinib
sourced from ClinicalTrials.gov · pharmadog mirrors structured fields, not the full protocol