clinical trial · NCT07143045
A Prospective Cohort Study of Zorifertinib as a First-line Treatment in Patients With Epidermal Growth Factor Receptor-mutant Advanced Non-small Cell Lung Cancer With Central Nervous System (CNS) Metastases
Alpha Biopharma (Jiangsu) Co., Ltd.·—·recruiting·n = 800
EGFR Mutant Advanced Non-small Cell Lung CancerCentral Nervous System (CNS) Metastaseszorifertinib
brief summary
This study is a patient-centered, two-group, three-cohort, multi-center, prospective study to further evaluate the survival benefits and safety of zorifertinib as a first-line treatment in EGFRm+ advanced NSCLC patients with CNS metastases, and to compare the clinical value of zorifertinib with other epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs).
started
Dec 29, 2025
primary completion
May 1, 2031
completion
Nov 1, 2031
last updated
Feb 9, 2026
sourced from ClinicalTrials.gov · pharmadog mirrors structured fields, not the full protocol