clinical trial · NCT06904365
Ovarian-Sparing Adaptive Radiotherapy in Young Adult Women
Uterine CancerRectal CancerColon CancerBreast CancerLung CancerSarcomaCervix CancerHead and Neck CancerHyperSight cone beam computed tomography (CBCT) scanETHOS 2.0
brief summary
Female patients with early onset (\<50 years old) pelvic malignancies such as uterine and rectal cancers are rising in incidence, which often requires pelvic radiation; many of these patients are premenopausal and at a high risk of premature ovarian failure from radiotherapy. Premature ovarian failure carries significant cardiac, musculoskeletal, sexual, and psychosocial morbidity. Ovarian transposition carries variable success rates, is not readily accessible to the general population, and can still be at risk of clinically significant radiotherapy doses. There is an unmet need for innovative techniques to protect ovarian function.
started
Apr 8, 2025
primary completion
Aug 17, 2026
completion
Aug 17, 2026
last updated
Aug 24, 2026
official title
Ovarian-Sparing Adaptive Radiotherapy in Young Adult Women (OvAR-Y): an In-Silico Feasibility Trial
sourced from ClinicalTrials.gov · pharmadog mirrors structured fields, not the full protocol