clinical trial · NCT06809569
A Study to Evaluate Laser Speckle Contrast Imaging to Assess Changes in Chemical Agent-Induced Skin Blood Flow in Healthy Participants (MK-0000-420)
Merck Sharp & Dohme LLC·phase1·completed·n = 12
HealthyAllyl Isothiocyanate (AITC)CapsaicinVehicle for AITCVehicle for Capsaicin
brief summary
Pain is a significant issue and there is a need for better treatments for pain management. Local changes in skin blood flow can be used as an indicator of pain in the body. Capsaicin and allyl isothiocyanate (AITC) increase blood flow and cause pain. The purpose of this study is to evaluate the use of laser speckle contrast imaging (LSCI) as a tool to assess changes in skin blood flow. Researchers want to learn about the effect size and reproducibility of using LSCI to measure the blood flow response to capsaicin and AITC.
started
Sep 25, 2023
primary completion
Dec 15, 2023
completion
Dec 15, 2023
last updated
Feb 5, 2025
official title
A Pilot Study to Evaluate the Use of Laser Speckle Contrast Imaging on Changes in Dermal Blood Flow Induced by Intradermal Capsaicin and Topical AITC in Healthy Participants
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