Exploring the Benefit of Topical Capsaicin in Treating Pain From Chemo-induced Peripheral Neuropathy: a Longitudinal Single Center Pilot Study

Primary Objectives

• To assess changes in Gait (specifically looking at velocity) before and after use of topical capsaicin.

Secondary Objectives

* To assess Pain intensity numerical rating scale (NRS) scores in chemotherapy induced peripheral neuropathy (CIPN) participants before and after use of capsaicin 8% topical patch. * To assess changes in quantitative sensory testing (QST) before and after use of topical capsaicin. * To assess skin punch biopsy to compare the integrity of epidermal nerve fibers and Meissner's corpuscles (MC) in CIPN patients before and after use of topical capsaicin (optional). * To assess pain tumor related neuropathy assessment scale (TNAS) before and after topical capsaicin * To assess pain interference using the Brief Pain Inventory (BPI), before and after topical capsaicin * To assess Patient Global Impression of Change (PGIC) * To assess the rate of adverse events and tolerability of topical capsaicin as reported by participants