clinical trial · NCT06644742
PKP2-ACM Natural History Study
CardiomyopathiesHeart DiseasesCardiovascular DiseasesGenetic Diseases
brief summary
The goal of this study is to describe the natural history and clinical events for patients who have Arrhythmogenic Cardiomyopathy with Pathogenic Plakophilin-2 Variants (PKP2-ACM) managed with standard of care.
started
Mar 1, 2026
primary completion
Dec 1, 2030
completion
Apr 1, 2031
last updated
Feb 27, 2026
detailed description
This is an observational study with both retrospective and prospective data collection. The study is designed to describe the natural history of PKP2-ACM including the signs and symptoms, key clinical events, and impact of the disease on quality of life. A hybrid (retrospective and prospective data collection) approach is being taken with the aim of achieving robust and longitudinal data generation.
official title
The Natural History of Arrhythmogenic Cardiomyopathy With Pathogenic Plakophilin-2 Variants (PKP2-ACM): An Observational Cohort Study
sourced from ClinicalTrials.gov · pharmadog mirrors structured fields, not the full protocol