clinical trial · NCT06064539
Study of Drug-drug Interaction of the Effects of Gemfibrozil and Rifampicin on SAR442168 in Healthy Adult Subjects
Multiple SclerosisTolebrutinibgemfibrozilrifampicin
brief summary
This is a Phase 1, single-center, open-label, non-randomized study to assess the effects of CYP2C8 inhibition using gemfibrozil, and CYP3A4 and CYP2C8 induction using rifampicin on the pharmacokinetics of SAR442168 in healthy male participants aged 18 to 45 years.
started
May 18, 2020
primary completion
Jul 8, 2020
completion
Jul 8, 2020
last updated
Sep 17, 2025
detailed description
Study duration per participant approximately 16 days for Cohort 1 and approximately 18 days for Cohort 2.
official title
A Phase 1, Single-center, Open-label, Two-cohort, Two-period, One-sequence, Two Treatment, Drug-drug Interaction Study of the Effects of Gemfibrozil and Rifampicin on SAR442168 in Healthy Subjects
sourced from ClinicalTrials.gov · pharmadog mirrors structured fields, not the full protocol