clinical trial · NCT05963698
The Fourth Left Atrial Appendage Occlusion Study
Hamilton Health Sciences Corporation·N/A·recruiting·n = 4,000
Atrial FibrillationStroke, IschemicSystemic EmbolismWATCHMAN device
brief summary
LAAOS-4 aims to determine if catheter-based endovascular left atrial appendage occlusion prevents ischemic stroke or systemic embolism in participants with atrial fibrillation, who remain at high risk of stroke, despite receiving ongoing treatment with oral anticoagulation.
started
Nov 30, 2023
primary completion
Sep 1, 2029
completion
Dec 1, 2029
last updated
Jun 8, 2026
detailed description
LAAOS-4 is a multicentre, prospective, open-label, randomized controlled trial with blinded assessment of endpoints (PROBE) to determine if catheter-based endovascular left atrial appendage occlusion prevents ischemic stroke or systemic embolism in participants with atrial fibrillation, who remain at high risk of stroke, despite receiving ongoing treatment with oral anticoagulation.
official title
The Fourth Left Atrial Appendage Occlusion Study (LAAOS-4)
sourced from ClinicalTrials.gov · pharmadog mirrors structured fields, not the full protocol