clinical trial · NCT05919264
FOG-001 in Locally Advanced or Metastatic Solid Tumors
Parabilis Medicines, Inc.·phase2·recruiting·n = 595
CancerColorectal CancerSolid TumorLocally Advanced Solid TumorMetastatic CancerWNT PathwayHCCDesmoidFOG-001mFOLFOX-6NivolumabTrifluridine/tipiracilBevacizumabFOG-001
brief summary
The goal of this clinical trial is to determine if FOG-001 is safe and effective in participants with locally advanced or metastatic solid tumors.
started
May 23, 2023
primary completion
Apr 1, 2027
completion
Aug 31, 2027
last updated
Apr 23, 2026
detailed description
This is a FIH, Phase 1/2, multicenter, open-label, non-randomized, dose escalation, dose expansion, and multiple subcutaneous dose study to evaluate the safety, tolerability, PK, pharmacodynamics, and antitumor activity of FOG-001 as monotherapy and in combination with other anticancer agents in participants with advanced or metastatic solid tumors likely or known to have a Wnt pathway activating mutation (WPAM).
official title
A Phase 1/2 Study of FOG-001 in Participants With Locally Advanced or Metastatic Solid Tumors
sourced from ClinicalTrials.gov · pharmadog mirrors structured fields, not the full protocol